Deatailed information for cohesin site CDBP00419454

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  • Basic information
  • CohesinDB ID: CDBP00419454
  • Locus: chr21-39311834-39323454
  • Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE64758, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, GSE50893, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, T-47D, A-549, HCAEC, Ramos, GM19238, HeLa, TC-71, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 66% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.200
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 91% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 22%, "7_Enh": 22%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, ZNF157, SOX5, ZNF211, E2F4, ZNF674, ZNF528, RFX3, KLF3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, CTBP1, ERF, STAT1, ZNF488, SAP130, ERG, ZBTB21, ZNF597, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, DACH1, CD74, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, HCFC1, MXI1, ZNF785, NR2C2, RELB, EP400, RUVBL2, RUNX1, HDAC1, NKX2-2, IRF3, CEBPA, ZNF707, REPIN1, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZXDC, ZBTB2, ELK1, ZBTB10, TFDP1, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, ZNF331, NR1H2, MBD1, GSPT2, IKZF5, ARID2, OVOL3, RBM25, ZSCAN31, AFF1, MBD2, ELL2, ETV4, NFATC3, ZSCAN18, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZNF510, TCF4, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZNF281, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, HNF1A, KDM4B, ZNF101, PBX2, SRSF4, ZNF596, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZBTB49, FUS, CTCF, JUN, TAF3, L3MBTL4, MNT, LMO1, ZBTB20, DPF2, RYBP, IRF4, DDX20, ZNF423, ZNF677, ZNF350, ZNF280A, PDX1, MLX, RBPJ, TFAP2C, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, NBN, CHD4, PBX1, ZNF329, ZNF626, KDM4A, HOMEZ, FOXP2, TSHZ1, ZNF2, RXRA, BATF3, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, LDB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, NFIB, BACH1, DAXX, ZNF48, ZEB2, NFYA, HMBOX1, PBX3, MAFB, NCAPH2, ETV6, HMGXB4, ZNF10, TEAD3, ZXDB, ZNF680, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, SALL4, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, KLF7, ZNF266, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, AGO2, ZNF768, TP53, ZNF645, NFKB1, ZSCAN22, ZNF140, PHF5A, BRD2, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, SPIN1, BRD4, CUX1, ZSCAN23, TBX2, ZNF468, PGR, FANCL, CBX5, SOX2, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, KLF1, SOX9, ZNF260, SOX4, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ELK4, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ZNF24, PHF21A, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, ZNF343, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, RBP2, INTS13, GATAD2B, TAF9B, ZNF777, NFYB, ZNF76, NCOA2, ZNF554, ETV5, GTF2A2, AHRR, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, MYBL2, RARA, NFYC, ZNF35, ZNF384, TAF15, CREBBP, ZNF169, NR0B1, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZNF264, ZMYM3, SUPT16H, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF223, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, NEUROG2, PKNOX1, ZNF547, RUVBL1, MYOD1, T, ZNF12, AR, KMT2D, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, MBD3, ZNF391, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF529, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, CREB3, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, ZNF300, ZNF585B, USP7, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ARNTL, ZNF501, JMJD6, FEZF1, TRPS1, HES1, TFE3, HBP1, EHF, IRF1, ZNF664, SREBF1, ZGPAT, NAB2, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF534, ZNF335, SMAD3, PCBP2, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, SMAD2, PBX4, NRF1, GR, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, ZNF213, ZNF837, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, MEF2D, BRCA1
  • Target gene symbol (double-evidenced CRMs): GET1,B3GALT5,SH3BGR,HMGN1,BRWD1,GET1-SH3BGR,LCA5L
  • Function elements
  • Human SNPs: Apolipoprotein_B_levels
  • Number of somatic mutations (coding): 136
  • Number of somatic mutations (non-coding): 94
  • Related genes and loops
  • Related gene: ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000182093, ENSG00000157578, ENSG00000185437, ENSG00000183778,
  • Related loop: chr21:38800000-38825000~~chr21:39325000-39350000, chr21:39200000-39225000~~chr21:39300000-39325000, chr21:39300000-39325000~~chr21:39400000-39425000, chr21:39300000-39325000~~chr21:39425000-39450000, chr21:39300000-39325000~~chr21:39600000-39625000, chr21:39300000-39325000~~chr21:39700000-39725000, chr21:39311821-39314792~~chr21:39387238-39389498, chr21:39311959-39313102~~chr21:39387388-39389691, chr21:39313200-39315343~~chr21:39347346-39350688, chr21:39313200-39315343~~chr21:39387575-39389929, chr21:39313201-39315232~~chr21:39347651-39350715, chr21:39313201-39315232~~chr21:39387637-39389565, chr21:39313213-39315341~~chr21:39347106-39349452, chr21:39313213-39315341~~chr21:39387404-39390232, chr21:39313217-39315223~~chr21:39347655-39350638, chr21:39313217-39315223~~chr21:39387388-39389691, chr21:39313225-39315438~~chr21:39347557-39350333, chr21:39313225-39315438~~chr21:39387253-39389877, chr21:39313233-39315495~~chr21:39387267-39389644, chr21:39313238-39315302~~chr21:39387310-39389980, chr21:39313242-39315444~~chr21:39387521-39389890, chr21:39313251-39315395~~chr21:39387315-39389934, chr21:39313256-39315329~~chr21:39387268-39389940, chr21:39313256-39315481~~chr21:39387441-39389598, chr21:39313266-39314748~~chr21:39387578-39389687, chr21:39313272-39315384~~chr21:39387528-39389909, chr21:39313277-39315384~~chr21:39387326-39389699, chr21:39313325-39314705~~chr21:39387024-39389430, chr21:39313325-39315275~~chr21:39387259-39389666, chr21:39313366-39315422~~chr21:39387902-39389468, chr21:39320997-39322719~~chr21:39347655-39350638, chr21:39325000-39350000~~chr21:39425000-39450000,
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