- Basic information
- CohesinDB ID: CDBP00419463
- Locus: chr21-39336590-39337662
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Data sourse: ENCSR167MTG, ENCSR000EEG, ENCSR338DUC, GSE143937, ENCSR000BKV, GSE67783, GSE72082, GSE206145-GSE177045, GSE25021, GSE76893, ENCSR000BLS, GSE105028, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE131606, GSE50893, ENCSR000EDW, GSE97394
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Cell type: MCF-7, Fibroblast, Hep-G2, GM2588, DKO, HUES64, GM19238, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 58%,
"5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: THAP11, NFIA, POU2F2, MEF2B, BCL6, SMC1A, POU5F1, ZNF600, XBP1, ZBTB48, WT1, GTF2F1, ZBTB33, SAP130, GATAD1, RXRB, HOXB13, KDM1A, ERG, RELA, ZBTB2, YY1, ASCL1, ZNF384, NEUROD1, MYC, HOMEZ, RAD21, GRHL3, OTX2, ZNF48, TAL1, XRCC5, ZNF614, ZNF143, CDK8, MITF, HMGXB4, ZNF736, DNMT3B, NR2F6, MIER3, NR3C1, SP7, TEAD3, NCOA3, TEAD1, KMT2A, CREB1, KLF6, TP73, MBD1, CTCF, PHF5A, ELF3, EP300, SPI1, NR4A1, ARID4B, ZNF644, ASH2L, ZBTB26, ZGPAT, BRD4, NFIL3, SMC3, GATAD2A, STAG1, ZNF316
- Target gene symbol (double-evidenced CRMs): LCA5L,ETS2,SH3BGR,GET1-SH3BGR,GET1,HMGN1
- Function elements
- Human SNPs: LDL_cholesterol_levels
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 13
- Related genes and loops
- Related gene:
ENSG00000157557,
ENSG00000205581,
ENSG00000285815,
ENSG00000182093,
ENSG00000157578,
ENSG00000185437,
- Related loop:
chr21:38800000-38825000~~chr21:39325000-39350000,
chr21:39325000-39350000~~chr21:39425000-39450000,
chr21:39335976-39337473~~chr21:39387323-39389534,
chr21:39336013-39337477~~chr21:39387504-39389563,