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Basic information

CohesinDB ID: CDBP00419476

Locus: chr21-39372448-39374699

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR198ZYJ, GSE112028, GSE130135, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE76815, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE131956, GSE111913, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, GM10847, GM2610, SLK, GM19240, HSPC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 46% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.356

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, HMG20A, SOX2, XBP1, FOXA1, PBX2, RXRB, HNRNPK, ZFP64, MXD4, PAX5, TP63, CDX2, ZNF467, TEAD1, TRIM28, BCLAF1, ELF1, ESR1, OCA2, MLL, HDAC8, CTCF, JUN, E4F1, ZNF695, MNT, SOX5, E2F6, ZNF528, SMC1, GATAD2A, RBPJ, TFAP2C, NANOG, POU2F2, CHD8, POU5F1, MYCN, BRD3, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, DUX4, SRF, GATAD1, SAP130, DDX5, ARID3A, ERG2, ZNF300, ERG, ZNF341, MYC, HOMEZ, RAD21, GRHL3, GABPA, XRCC5, ZNF614, IKZF1, MIER3, RCOR1, NR2F6, CEBPB, KMT2A, CREB1, EZH2, GRHL2, ZNF652, SPI1, MIXL1, ZNF257, GATA2, ZGPAT, MXI1, SMARCA5, MRTFB, NFIL3, ETV5, SMC1A, CBX1, CEBPA, NKX2-2, EZH2phosphoT487, ZFX, POU4F2, SMAD3, ZNF770, ZNF654, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZNF35, CREBBP, ZNF133, ZNF384, RUNX2, OSR2, ARNT, ZNF48, SMAD4, PBX3, CDK8, HMGXB4, MED1, TEAD3, ZNF680, PIAS1, SMAD1, NCOA1, L3MBTL2, ZNF41, MAFK, BCL11A, SP1, REST, ZNF479, ZBTB7A, ASH2L, HOXA9, PHIP, BCOR, SMC3, STAG2, STAG1, TRP47, FOXA2, CBX3, ZNF692, ZSCAN16, WT1, MAFF, ZNF30, GTF2B, MEF2C, HOXB13, YY1, RELA, SP140, HIF1A, GATA3, MAX, SPIB, ZNF143, CEBPG, TP53, PKNOX1, ZNF334, ELF3, BRD2, KAT8, BHLHE40, AR, ARID4B, EGLN2, ZBTB26, NCOR1, IKZF2, BRD4, JUND, CUX1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,PSMG1,BRWD1,GET1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093,

eachgene

Deatailed information for cohesin site CDBP00419476