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Basic information

CohesinDB ID: CDBP00419478

Locus: chr21-39378615-39382320

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE115602, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, GSE116344, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR981FDC, ENCSR247LSH, GSE62063, ENCSR000EHX, ENCSR748MVX, GSE206145, GSE55407, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, GM2610, SLK, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 32% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.444

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "2_TssAFlnk": 24%, "5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, ZSCAN5C, FOXA1, RXRB, HDGF, PRDM1, ZNF189, SMARCE1, KLF5, ELF1, KLF6, RBM39, ESR1, JUN, CTCF, KLF1, SOX5, DPF2, SOX6, TEAD4, FOXA3, GATAD2A, TFAP2C, MTA2, ZBTB17, DUX4, GATAD1, SAP130, TBP, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, NKX2-1, FOXK2, BATF3, STAT3, XRCC5, IKZF1, MIER3, RCOR1, NFRKB, CEBPB, KMT2A, SPI1, MIXL1, HDAC2, DRAP1, ZGPAT, ZNF766, NFIL3, ETV5, THAP11, BCL6, CEBPA, HDAC1, SOX13, ZNF534, ZFX, RARA, ZNF384, GATA4, ARNT, PBX4, ATF2, ZEB2, HMGXB4, ZEB1, TEAD3, KLF9, L3MBTL2, KLF16, ZBTB7A, ATF7, FOXA2, MIER2, ZBTB33, KLF7, YY1, RELA, NEUROD1, AHR, MAX, MTA1, ZNF333, ZFP69B, ZNF592, KLF4, CEBPG, NR2F2, ZNF512, TP53, ELF3, BRD2, AR, TAF1, ZBTB40, ZNF366, EGR1, ZBTB26, SCRT1, JUND, CLOCK, MAZ, DMAP1

Target gene symbol (double-evidenced CRMs): ERG,B3GALT5,PSMG1,GET1-SH3BGR,BRWD1,ETS2,GET1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 37

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419478