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Basic information

CohesinDB ID: CDBP00419481

Locus: chr21-39386888-39390967

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 83% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.111

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 91% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 25%, "2_TssAFlnk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, PITX3, HDAC8, ZNF561, ARID5B, SOX5, E2F4, ZNF674, DEK, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, ZNF263, BRD3, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, IRF3, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ATF2, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, EVI1, MBD1, GSPT2, IKZF5, ARID2, RBM25, AFF1, ELL2, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, SS18, ZNF17, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, MAF1, PLAG1, KLF4, ZFP69B, BCL11B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, TSC22D4, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, JUN, CTCF, TAF3, MNT, LMO1, ZBTB20, DPF2, RYBP, IRF4, ZNF423, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, ZNF2, HOMEZ, TSHZ1, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, ZNF585A, SOX13, AFF4, ZNF770, ZNF18, SP3, DAXX, BACH1, ARNT, ZNF48, HMBOX1, NFYA, ZEB2, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, ZFP42, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, ZNF490, NCOA2, NFYB, ZNF76, ETV5, BCL6, SIN3A, ERG3, RARA, NFYC, ZNF35, ZNF384, TAF15, CREBBP, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, NCOA1, GTF3C2, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, RUVBL1, MYOD1, AR, ZNF445, ZNF324, HEXIM1, ZNF280D, ZZZ3, AHR, DMAP1, MBD3, FOSL2, ZNF391, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, ZNF362, CTCFL, PRDM1, GLYR1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, USP7, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, JMJD6, TFE3, HBP1, ZNF664, IRF1, GTF3C5, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, PCBP2, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, SMAD2, NRF1, NR2C1, FOS, CHD1, SUPT5H, TGIF2, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, YY1, ZNF148, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): BRWD1,GET1-SH3BGR,ETS2,B3GALT5,PSMG1,GET1,ERG,HMGN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 156

Number of somatic mutations (non-coding): 54

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000182093, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419481