Deatailed information for cohesin site CDBP00419506

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  • Basic information
  • CohesinDB ID: CDBP00419506
  • Locus: chr21-39444581-39446444
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, GSE126634, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000EAC, GSE143937, GSE165895, ENCSR000BKV, GSE67783, GSE138405, GSE86191, GSE101921, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, GSE62063, ENCSR000EHX, ENCSR635OSG, ENCSR000BTQ, GSE38395, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411
  • Cell type: RH4, GM2610, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, hLCL, IMR-90, BCBL-1, K-562, HFFc6, H1-hESC, SNYDER, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, Ramos, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, Neutrophil, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 26% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.567
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 91% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 35%, "1_TssA": 26%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF426, FOXA1, HLF, RXRB, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, PAX8, E2F4, ZNF674, DEK, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, ZNF785, NR2C2, DRAP1, MXI1, RELB, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, EVI1, GSPT2, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, NFATC3, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZNF281, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, ILF3, FOSL1, SMARCA2, ZNF660, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, WDHD1, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZBTB17, ZBTB48, NONO, SRF, NBN, KDM4A, HOMEZ, ZNF2, FOXP2, TSHZ1, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, DAXX, BACH1, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ATF7, ASH2L, CTBP2, SMC3, STAG1, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, FANCL, PATZ1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ZNF217, ESR1, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZNF778, KDM4C, ZSCAN5A, ERG2, SP4, TBP, OGG1, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, NCOA2, ZNF76, NFYB, ETV5, BCL6, SIN3A, ZFP37, ERG3, CREBBP, ZNF384, RARA, ZNF35, TAF15, NFYC, SMAD4, ZNF518A, CDK8, ZEB1, SREBF2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, RUVBL1, KMT2D, AR, YAP1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, INSM2, ZNF362, CTCFL, KLF14, MECOM, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ZNF205, GATAD1, GMEB2, ARID3A, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, FEZF1, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, HEXIM1-CDK9, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, NRF1, NR2C1, CHD1, FOS, SUPT5H, TGIF2, MED1, KDM6B, MYB, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, BRCA1, SP140, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): HMGN1,GET1-SH3BGR,BRWD1,ETS2,LCA5L,PSMG1,SH3BGR
  • Function elements
  • Human SNPs: Pulse_pressure
  • Number of somatic mutations (coding): 26
  • Number of somatic mutations (non-coding): 7
  • Related genes and loops
  • Related gene: ENSG00000157557, ENSG00000183527, ENSG00000185658, ENSG00000205581, ENSG00000285815, ENSG00000157578, ENSG00000185437,
  • Related loop: chr21:38504739-38507562~~chr21:39440834-39442538, chr21:38525000-38550000~~chr21:39450000-39475000, chr21:38800000-38825000~~chr21:39425000-39450000, chr21:39000000-39025000~~chr21:39425000-39450000, chr21:39152734-39154644~~chr21:39445170-39446634, chr21:39175000-39200000~~chr21:39425000-39450000, chr21:39200000-39225000~~chr21:39425000-39450000, chr21:39225000-39250000~~chr21:39425000-39450000, chr21:39300000-39325000~~chr21:39425000-39450000, chr21:39325000-39350000~~chr21:39425000-39450000,
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