- Basic information
- CohesinDB ID: CDBP00419508
- Locus: chr21-39451104-39454021
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Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE67783, GSE72082, GSE165895, ENCSR879KXD, GSE105028, GSE101921, ENCSR153HNT, GSE83726, ENCSR703TNG, GSE25021, GSE116344, GSE115602
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Cell type: MCF-7, HMEC, RH4, H9-hESC, K-562, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
91% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 26%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, ZNF660, SOX2, MEIS2, XBP1, PATZ1, FOXA1, KDM4B, ZNF101, HLF, RBFOX2, PBX2, UBTF, ZNF28, ZFHX2, HDGF, ZNF274, ATF3, NFIC, ZFP64, CHD7, ZBTB44, IKZF3, PRDM1, ATF4, ZNF189, SMARCE1, ZSCAN4, ZNF467, MYOG, ZNF629, KLF5, ELF1, TEAD1, ETV1, RBM39, KLF6, ZNF217, ESR1, SMAD5, LMO2, OCA2, HDAC8, USF2, ZFP91, CTCF, JUN, BAF155, E4F1, EP300, ZBTB20, MNT, ZNF695, SOX5, DPF2, E2F6, PRDM4, TRIM24, RFX5, SOX6, E2F4, ZNF674, CREB3, E2F1, ZNF528, ZNF350, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, EED, GLIS1, NANOG, CHD8, POU2F2, POU5F1, ZNF263, MYCN, ID3, TOP2A, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN21, SRF, ZMYND8, NBN, ARID3A, SP4, TBP, ERG, ZBTB21, ZNF341, MYC, ONECUT1, SMARCA4, RFX1, ARID1B, RAD21, GRHL3, FOXK2, GABPA, STAT3, XRCC5, ZNF398, IKZF1, RCOR1, ZNF639, NFRKB, VDR, DACH1, NR3C1, ESRRA, CEBPB, CREB1, EZH2, GRHL2, FEZF1, IRF1, HDAC2, GATA2, ZNF644, SIX2, HCFC1, NR2C2, EP400, NFYB, ZNF554, NFIL3, ATF1, CC2D1A, RUNX1, CBX1, SMC1A, HDAC1, CEBPA, ZNF335, ZFX, SIN3A, SOX13, ZNF534, SMAD3, ZFP37, TET2, ERG3, ZMIZ1, SMARCC1, PRDM10, MEF2A, ZXDC, ZNF35, ZNF384, CREBBP, IRF2, BRD9, RUNX2, GATA4, OSR2, ZNF184, SP3, ARNT, NRF1, ELK1, BACH1, PBX4, ATF2, SMAD4, ZEB2, ZNF518A, FOXM1, NFYA, SP2, FOS, NR2C1, HMBOX1, CDK8, MAFB, MED1, ZNF584, PML, ZNF558, SCRT2, PIAS1, SMAD1, VEZF1, TAF7, NR1H2, ZNF879, C11orf30, L3MBTL2, TBX5, KLF16, SP1, BCL11A, TFAP2A, HNF4A, NR4A1, GSPT2, NKX2-5, REST, ZBTB7A, ARID2, RBM25, POU2F3, ATF7, HNRNPLL, PHIP, AFF1, FOXP1, ZNF623, SMC3, STAG2, STAG1, MLLT1, ZNF394, NFATC3, PAX7, PTTG1, KLF13, PPARG, FOXA2, MTA3, CREM, RBBP5, SAFB, ZNF600, ZNF692, ZSCAN16, WT1, GTF2B, ESR2, ZBTB33, HOXB13, ZNF318, KDM1A, YY1, RELA, ZNF589, TARDBP, CREB3L1, NEUROD1, JUNB, SP140, ZIC2, HIF1A, ZFP36, ZNF830, SKIL, GATA3, OTX2, TCF4, MGA, TAL1, MAX, NRIP1, ZNF143, ZNF449, PLAG1, TLE3, ZFP69B, ZNF592, SP7, GFI1B, CEBPG, ZKSCAN8, CBX2, BCL11B, ZNF791, NR2F1, KDM5B, NCOA3, TCF7L2, PKNOX1, TP53, ZNF334, ZSCAN22, MYOD1, EGR2, PHOX2B, BRD2, BHLHE40, AR, PTRF, TAF1, ZNF579, ZBTB40, ZNF324, EGLN2, ZNF366, EGR1, HSF1, MYNN, RNF2, BRD4, SCRT1, JUND, ILF3, CUX1, MAZ, ZSCAN23, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ERG,GET1-SH3BGR,SH3BGR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 272
- Number of somatic mutations (non-coding): 46
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000285815,
ENSG00000185437,
- Related loop:
chr21:38525000-38550000~~chr21:39450000-39475000,
chr21:38800000-38825000~~chr21:39425000-39450000,
chr21:39000000-39025000~~chr21:39425000-39450000,
chr21:39152734-39154644~~chr21:39445170-39446634,
chr21:39175000-39200000~~chr21:39425000-39450000,
chr21:39200000-39225000~~chr21:39425000-39450000,
chr21:39225000-39250000~~chr21:39425000-39450000,
chr21:39300000-39325000~~chr21:39425000-39450000,
chr21:39325000-39350000~~chr21:39425000-39450000,