- Basic information
- CohesinDB ID: CDBP00419524
- Locus: chr21-39514883-39522284
-
Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 83% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.122
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 44%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: IRF4, CBX2, EZH2, MYC
- Target gene symbol (double-evidenced CRMs): B3GALT5,GET1-SH3BGR,SH3BGR,PCP4
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 60
- Number of somatic mutations (non-coding): 50
- Related genes and loops
- Related gene:
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
- Related loop:
chr21:39500000-39525000~~chr21:39600000-39625000,
chr21:39500000-39525000~~chr21:39675000-39700000,
chr21:39500000-39525000~~chr21:39700000-39725000,
chr21:39500000-39525000~~chr21:39775000-39800000,
chr21:39500000-39525000~~chr21:39850000-39875000,
chr21:39500000-39525000~~chr21:39900000-39925000,
chr21:39500000-39525000~~chr21:39925000-39950000,
chr21:39500000-39525000~~chr21:40025000-40050000,
chr21:39500000-39525000~~chr21:40050000-40075000,
chr21:39500000-39525000~~chr21:40100000-40125000,
chr21:39500000-39525000~~chr21:40125000-40150000,
chr21:39500000-39525000~~chr21:40350000-40375000,
chr21:39500000-39525000~~chr21:41075000-41100000,
chr21:39517168-39519542~~chr21:39705393-39707110,
chr21:39517168-39519542~~chr21:39715040-39717158,
chr21:39517168-39519542~~chr21:39725249-39727184,
chr21:39517259-39519458~~chr21:39714980-39716790,
chr21:39517259-39519458~~chr21:40120108-40122096,
chr21:39517261-39519776~~chr21:39714731-39716796,
chr21:39517288-39519777~~chr21:39715026-39717283,
chr21:39517297-39519497~~chr21:39714676-39716787,
chr21:39517303-39519751~~chr21:39705185-39706929,
chr21:39517303-39519751~~chr21:39712480-39713816,
chr21:39517303-39519751~~chr21:39715020-39717112,
chr21:39517303-39519751~~chr21:39787215-39789565,
chr21:39517308-39519721~~chr21:39714941-39716803,
chr21:39517315-39519547~~chr21:39714729-39716798,
chr21:39517315-39519547~~chr21:39910639-39912376,
chr21:39517315-39519547~~chr21:40120304-40121958,
chr21:39517322-39519410~~chr21:39715065-39716809,
chr21:39517329-39519377~~chr21:39715066-39716784,
chr21:39517336-39519705~~chr21:39715042-39717340,
chr21:39517343-39519431~~chr21:39715064-39716775,
chr21:39517353-39519456~~chr21:39715029-39716810,
chr21:39517354-39519438~~chr21:39629845-39631913,
chr21:39517354-39519438~~chr21:39705387-39706980,
chr21:39517354-39519438~~chr21:39712470-39713909,
chr21:39517354-39519438~~chr21:39715117-39716791,
chr21:39517358-39519642~~chr21:39705371-39706965,
chr21:39517358-39519642~~chr21:39714870-39717016,
chr21:39517360-39519534~~chr21:39705354-39706952,
chr21:39517360-39519534~~chr21:39712511-39713822,
chr21:39517360-39519534~~chr21:39715036-39716800,
chr21:39517368-39519427~~chr21:39715102-39716748,
chr21:39517369-39519405~~chr21:39715081-39716789,
chr21:39517370-39519432~~chr21:39715121-39716751,
chr21:39517370-39519511~~chr21:39715052-39716779,
chr21:39517372-39519496~~chr21:39715100-39716804,
chr21:39517377-39519678~~chr21:39715115-39716829,
chr21:39517379-39519777~~chr21:39714973-39716797,
chr21:39517380-39519751~~chr21:39714950-39717021,
chr21:39517407-39519894~~chr21:39705344-39706807,
chr21:39517407-39519894~~chr21:39715098-39716781,
chr21:39517409-39519453~~chr21:39715079-39716803,
chr21:39517410-39519337~~chr21:39715310-39716764,
chr21:39517417-39519653~~chr21:39715029-39716795,
chr21:39517439-39519408~~chr21:39715248-39716850,
chr21:39517449-39519764~~chr21:39714705-39716820,
chr21:39517449-39519764~~chr21:39725321-39727028,
chr21:39517500-39519305~~chr21:39715098-39716750,
chr21:39517500-39519881~~chr21:39715027-39716807,
chr21:39517539-39519419~~chr21:39714972-39716820,
chr21:39517541-39519337~~chr21:39715220-39716785,
chr21:39517544-39519746~~chr21:39705156-39706958,
chr21:39517544-39519746~~chr21:39715029-39716799,
chr21:39517545-39519545~~chr21:39715058-39716803,
chr21:39517560-39519419~~chr21:39715031-39716746,
chr21:39517570-39519399~~chr21:39715260-39716808,
chr21:39517570-39519399~~chr21:40120443-40121742,
chr21:39517583-39519436~~chr21:39715151-39716788,
chr21:39517618-39519383~~chr21:39715097-39716777,
chr21:39517656-39519379~~chr21:39715099-39716759,
chr21:39517703-39519567~~chr21:39715099-39716856,
chr21:39517712-39519561~~chr21:39715048-39716830,
chr21:39517734-39519372~~chr21:39715080-39716802,
chr21:39517800-39519427~~chr21:39715053-39716761,
chr21:39517814-39519374~~chr21:39715017-39716720,
chr21:39517826-39519509~~chr21:39714989-39716693,
chr21:39517837-39519461~~chr21:39715046-39716689,
chr21:39517839-39519351~~chr21:39714993-39716666,
chr21:39517856-39519435~~chr21:39714989-39716725,
chr21:39517859-39519254~~chr21:39715322-39716629,
chr21:39517864-39519219~~chr21:39715357-39716651,
chr21:39525000-39550000~~chr21:39625000-39650000,
chr21:39525000-39550000~~chr21:39700000-39725000,
chr21:39525000-39550000~~chr21:40075000-40100000,
chr21:39525000-39550000~~chr21:40100000-40125000,
chr21:39525000-39550000~~chr21:40125000-40150000,