- Basic information
- CohesinDB ID: CDBP00419547
- Locus: chr21-39601006-39602588
-
Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 37%,
"14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, XBP1, FOXA1, SUZ12, ZFHX2, ATF3, MORC2, TEAD1, ESR1, CTCF, JUN, E2F6, ZNF528, PDX1, TFAP2C, GLIS1, ZNF425, POU2F2, MYCN, ZNF263, TOP2A, POU5F1, ZNF239, DUX4, ZBTB48, ERG2, ERG, ASCL1, ETS1, MYC, SMARCA4, GABPA, STAT3, XRCC5, NKX3-1, RCOR1, NR3C1, ESRRA, CREB1, EZH2, ZHX2, SPI1, GATA2, SIX2, RUNX1, SMC1A, NKX2-2, ZFX, TET2, ERG3, ZNF384, OSR2, ARNT, ATF2, FOS, MED1, PIAS1, ZMYM3, KLF9, BCL11A, REST, RBM25, POU2F3, AATF, SMC3, STAG1, TRP47, CBFA2T2, TBL1X, FOXA2, CBX3, RBBP5, WT1, HOXB13, KDM1A, YY1, RELA, SP140, OTX2, GATA3, MAX, ZNF143, HAND2, CBX2, TLE3, NR2F1, NEUROG2, TP53, ZNF334, MYOD1, EGR2, PHOX2B, AR, RXR, ZBTB42, HEXIM1, HSF1, NOTCH3, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): ETS2,BRWD1,MX1,B3GALT5,PCP4,SH3BGR,GET1-SH3BGR,ERG
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 6
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000157554,
ENSG00000157557,
ENSG00000185658,
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
ENSG00000157601,
- Related loop:
chr21:35775000-35800000~~chr21:39600000-39625000,
chr21:38375000-38400000~~chr21:39600000-39625000,
chr21:38525000-38550000~~chr21:39600000-39625000,
chr21:38625000-38650000~~chr21:39600000-39625000,
chr21:38800000-38825000~~chr21:39600000-39625000,
chr21:38850000-38875000~~chr21:39600000-39625000,
chr21:39200000-39225000~~chr21:39600000-39625000,
chr21:39225000-39250000~~chr21:39600000-39625000,
chr21:39300000-39325000~~chr21:39600000-39625000,
chr21:39500000-39525000~~chr21:39600000-39625000,
chr21:39600000-39625000~~chr21:39700000-39725000,
chr21:39600000-39625000~~chr21:39850000-39875000,
chr21:39600000-39625000~~chr21:39900000-39925000,
chr21:39600000-39625000~~chr21:39950000-39975000,
chr21:39600000-39625000~~chr21:40050000-40075000,
chr21:39600000-39625000~~chr21:40075000-40100000,
chr21:39600000-39625000~~chr21:40100000-40125000,
chr21:39600000-39625000~~chr21:41000000-41025000,
chr21:39600000-39625000~~chr21:41075000-41100000,
chr21:39600000-39625000~~chr21:41425000-41450000,