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Basic information

CohesinDB ID: CDBP00419548

Locus: chr21-39604265-39605410

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015

Cell type: MCF-7, RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: Mau2,SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 45%, "14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MED1, ZNF384, NCOA3, SCRT2, ZFX, EZH2, SP140, HIF1A, SCRT1, ZSCAN5A, WT1, ARNT, GRHL3, PRDM9, CLOCK, SUZ12, CTCF, DNMT3B, YY1

Target gene symbol (double-evidenced CRMs): PCP4,ETS2,MX1,GET1-SH3BGR,ERG,SH3BGR,B3GALT5,BRWD1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 11

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000185658, ENSG00000285815, ENSG00000185437, ENSG00000183778, ENSG00000183036, ENSG00000157601,

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Deatailed information for cohesin site CDBP00419548