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Basic information

CohesinDB ID: CDBP00419551

Locus: chr21-39609628-39615120

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE25021, GSE165895, GSE115602, ENCSR000BTU, GSE67783, GSE122299, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE118494, GSE98367, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE129526, GSE111913, GSE68388, GSE83726

Cell type: RH4, CVB-hiPSC, CVI-hiPSC, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, HFFc6, H1-hESC, Monocytes, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, HCT-116, HEK293T, Neurons-H1, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 18% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.767

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 17%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, GLIS1, BRD1, ZNF263, MYCN, ZFX, ZBTB48, WT1, TET2, ERG, ATF3, MYC, SP140, TAL1, EZH2, CTCF, SPI1, PAX3-FOXO1, HSF1, MAZ, STAG1

Target gene symbol (double-evidenced CRMs): ERG,BRWD1,PCP4,SH3BGR,GET1-SH3BGR,B3GALT5,MX1,ETS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 50

Number of somatic mutations (non-coding): 41

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000185658, ENSG00000285815, ENSG00000185437, ENSG00000183778, ENSG00000183036, ENSG00000157601,

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Deatailed information for cohesin site CDBP00419551