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Basic information

CohesinDB ID: CDBP00419552

Locus: chr21-39616321-39616816

Data sourse: GSE206145-GSE177045

Cell type: MCF-7

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.989

Subunit: Mau2,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 50%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOSL1, PGR, TRIM25, ZNF660, SOX2, NME2, XBP1, PATZ1, FOXA1, SUZ12, PBX2, RING1B, ZFHX2, TFAP4, HNRNPK, MEN1, LYL1, ATF3, ZFP64, CTCFL, CHD7, IKZF3, MORC2, ZNF189, SMARCE1, TP63, ZSCAN4, MITF, ZNF320, ZNF736, HDAC3, ZNF467, ZNF629, JMJD1C, TEAD1, TRIM28, ELF1, KLF6, ETV1, KLF10, SAP30, ESR1, OCA2, ZNF217, HNF1B, LMO2, ZNF561, CTCF, JUN, TCF12, EP300, BAF155, ZBTB20, GATA6, RYBP, DPF2, E2F6, TRIM24, ZNF423, E2F1, ZNF528, TEAD4, PDX1, TFAP2C, EED, GLIS1, JARID2, NANOG, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, KDM4C, POU2F2, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZNF649, ERF, DDX5, ERG2, SP4, TBP, HOXC5, ZBTB21, ERG, ZBTB8A, ZNF341, MYC, ETS1, TSHZ1, RFX1, RAD21, KDM4A, GRHL3, GABPA, APC, STAT3, NKX3-1, ZNF398, PRDM14, RCOR1, ZNF639, NR3C1, CEBPB, ESRRA, CREB1, EZH2, KLF8, GRHL2, EBF3, TRPS1, PHF8, ZHX2, SPI1, KLF17, IRF1, ZBTB14, HDAC2, GATA2, SIX2, FLI1, MXI1, ZNF554, RUNX1, SMC1A, CBX1, EZH2phosphoT487, IRF3, SIRT6, ZNF335, ZFX, POU4F2, SIN3A, NKX2-2, SMAD3, TET2, ERG3, CBX8, SMARCC1, PRDM10, CREBBP, ZNF35, RUNX2, OSR2, ZNF184, ARNT, NRF1, PBX4, DAXX, ATF2, PRDM9, ZEB2, ZNF518A, ETV6, NCAPH2, ZNF10, FOS, CHD1, SP2, CDK8, MAFB, MED1, TEAD3, ZNF264, PIAS1, ZMYM3, TAF7, KLF9, HOXA9, STAT5A, SP1, BCL11A, TFAP2A, NIPBL, REST, ZBTB7A, RBM25, POU2F3, ASH2L, HNRNPLL, PCGF2, CTBP2, BCOR, GLIS2, FOXP1, ZNF543, PHIP, AATF, MBD2, SMC3, STAG1, TRP47, FOXA2, RBBP5, CHD2, SS18, MEIS1, ZNF600, ZNF692, ZSCAN16, WT1, GTF2B, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, PCGF1, ZFP36, GATA3, MAF1, MAX, TAL1, NRIP1, ZNF143, MTA1, GATA1, HAND2, CBX2, TLE3, KLF4, SP7, NCOA3, NR2F2, ZNF768, TCF7L2, KDM5B, TP53, EGR2, PHOX2B, T, ELF3, BRD2, BHLHE40, AR, TAF1, ZBTB16, YAP1, ZNF324, RXR, ZNF366, ZBTB42, HEXIM1, TFIIIC, HSF1, ZBTB26, EGR1, JUND, BRD4, CLOCK, MAZ, ZSCAN23, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): SH3BGR,GET1-SH3BGR,ERG,ETS2,B3GALT5,BRWD1,PCP4,MX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000157554, ENSG00000157557, ENSG00000185658, ENSG00000285815, ENSG00000185437, ENSG00000183778, ENSG00000183036, ENSG00000157601,

eachgene

Deatailed information for cohesin site CDBP00419552