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Basic information

CohesinDB ID: CDBP00419554

Locus: chr21-39629704-39632293

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE131606, ENCSR330ELC, GSE25021, ENCSR000BUC, GSE115602, ENCSR000BTU, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR199XBQ, ENCSR703TNG, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE129526, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, GSE68388, ENCSR748MVX

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, HEK293T, Hep-G2, MCF-10A, Neurons-H1, Ishikawa, A-549, SLK, DKO, HUES64, SK-N-SH, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 30% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 69% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 29%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF660, MEIS2, HNF1A, XBP1, FOXA1, SUZ12, MLL4, ATF3, NFIC, CHD7, PRDM1, ATF4, PAX5, CDX2, KLF5, TEAD1, KLF6, ETV1, ESR1, HNF1B, USF2, CTCF, TCF12, JUN, EP300, BAF155, GATA6, E2F1, TEAD4, PDX1, CHD8, BRD3, KDM4C, ZNF317, ZBTB48, STAT1, HOXC5, PAX6, ERG, ETS1, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, NKX2-1, PROX1, BATF3, STAT3, UBN1, NKX3-1, RCOR1, VDR, NR3C1, CEBPB, CREB1, EPAS1, EZH2, BMPR1A, ZHX2, EHF, IRF1, GATA2, ZNF766, ZNF554, RUNX1, SMC1A, CBX1, NKX2-2, EZH2phosphoT487, SIN3A, ZFX, FIP1L1, SMAD3, ERG3, SMARCC1, PRDM10, RUNX2, CDK6, GR, ZNF184, PBX4, DAXX, ARNT, ZNF48, ZNF518A, PBX3, MAFB, FOXM1, FOS, CDK8, CHD1, MED1, ZEB1, NR1H2, MAFK, SP1, NIPBL, USF1, HNF4A, REST, ARID1A, ZNF479, PHIP, FOXP1, SMC3, NCOR2, STAG2, STAG1, PPARG, FOXA2, CBX3, SS18, ZNF692, MEF2C, HOXB13, YY1, RELA, JUNB, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, KLF4, ZFP69B, SP7, NCOA3, BAP1, TCF7L2, KDM5B, TP53, ZNF547, MYOD1, ELF3, BRD2, BHLHE40, AR, PAX3-FOXO1, TAF1, ZNF324, JUND, BRD4, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): GET1,BRWD1,SH3BGR,B3GALT5,PSMG1,GET1-SH3BGR

Function elements

Human SNPs: .

Number of somatic mutations (coding): 14

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093, ENSG00000185437, ENSG00000183778,

eachgene

Deatailed information for cohesin site CDBP00419554