Deatailed information for cohesin site CDBP00419555

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  • Basic information
  • CohesinDB ID: CDBP00419555
  • Locus: chr21-39632853-39634794
  • Data sourse: GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE131606, ENCSR330ELC, GSE165895, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR806UKK, GSE138105, ENCSR703TNG, ENCSR199XBQ, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, GSE68388, ENCSR748MVX
  • Cell type: MCF-7, RPE, Fibroblast, HCT-116, SLK, A-549, DKO, SK-N-SH, HSPC, HuCC-T1, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 19% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.878
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 69% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 28%, "15_Quies": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF660, MEIS2, HNF1A, XBP1, FOXA1, SUZ12, MLL4, ATF3, NFIC, CHD7, PRDM1, ATF4, PAX5, CDX2, KLF5, TEAD1, KLF6, ETV1, ESR1, HNF1B, USF2, CTCF, TCF12, JUN, EP300, BAF155, GATA6, E2F1, TEAD4, PDX1, CHD8, BRD3, KDM4C, ZNF317, ZBTB48, STAT1, HOXC5, PAX6, ERG, ETS1, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, NKX2-1, PROX1, BATF3, STAT3, UBN1, NKX3-1, RCOR1, VDR, NR3C1, CEBPB, CREB1, EPAS1, EZH2, BMPR1A, ZHX2, EHF, IRF1, GATA2, ZNF766, ZNF554, RUNX1, SMC1A, CBX1, NKX2-2, EZH2phosphoT487, SIN3A, ZFX, FIP1L1, SMAD3, ERG3, SMARCC1, PRDM10, RUNX2, CDK6, GR, ZNF184, PBX4, DAXX, ARNT, ZNF48, ZNF518A, PBX3, MAFB, FOXM1, FOS, CDK8, CHD1, MED1, ZEB1, NR1H2, MAFK, SP1, NIPBL, USF1, HNF4A, REST, ARID1A, ZNF479, PHIP, FOXP1, SMC3, NCOR2, STAG2, STAG1, PPARG, FOXA2, CBX3, SS18, ZNF692, MEF2C, HOXB13, YY1, RELA, JUNB, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, KLF4, ZFP69B, SP7, NCOA3, BAP1, TCF7L2, KDM5B, TP53, ZNF547, MYOD1, ELF3, BRD2, BHLHE40, AR, PAX3-FOXO1, TAF1, ZNF324, JUND, BRD4, MAZ, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,B3GALT5,PSMG1,BRWD1,GET1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 22
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093, ENSG00000183778,
  • Related loop: chr21:39175000-39200000~~chr21:39625000-39650000, chr21:39375000-39400000~~chr21:39625000-39650000, chr21:39517354-39519438~~chr21:39629845-39631913, chr21:39525000-39550000~~chr21:39625000-39650000, chr21:39625000-39650000~~chr21:41650000-41675000, chr21:39625000-39650000~~chr21:42975000-43000000, chr21:39633375-39634630~~chr21:39715081-39716789,
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