Deatailed information for cohesin site CDBP00419558

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  • Basic information
  • CohesinDB ID: CDBP00419558
  • Locus: chr21-39638015-39640435
  • Data sourse: GSE67783, GSE72082, GSE86191, GSE98367, GSE111913, GSE206145, GSE120943, GSE68388, ENCSR703TNG, GSE25021
  • Cell type: MCF-7, RPE, HCT-116, Monocytes, HuCC-T1, RT-112, HSPC, Macrophage
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 4% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.911
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 69% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 25%, "14_ReprPCWk": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, PGR, SOX2, XBP1, HNF1A, FOXA1, PBX2, ZFHX2, TFAP4, CHD7, MORC2, ZNF189, TP63, CDX2, KLF5, TEAD1, TRIM28, KLF6, SAP30, ESR1, HNF1B, ZFP91, CTCF, TCF12, EP300, KLF1, BAF155, MNT, SOX9, E2F6, ZNF512B, ZNF528, TEAD4, PDX1, TFAP2C, EED, GLIS1, NANOG, CHD8, BRD1, ZNF263, POU5F1, MYCN, TOP2A, CTBP1, ZNF317, ZBTB17, ZBTB48, DDX5, ERG2, HOXC5, ERG, ASCL1, ONECUT1, MYC, EOMES, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, NKX3-1, DACH1, NR3C1, CEBPB, CREB1, EZH2, GRHL2, ZHX2, IRF1, KLF17, HDAC2, GATA2, SIX2, SREBF1, NCOA2, RUNX1, CBX1, NKX2-2, SIN3A, ZFX, SMAD3, ERG3, CREBBP, PBX4, ARNT, ATF2, MAFB, FOS, CHD1, MED1, PIAS1, USF1, NIPBL, SP1, HNF4A, POU2F3, ASH2L, CTBP2, PHIP, BCOR, FOXP1, AATF, SMC3, STAG1, ZNF283, CBFA2T2, FOXA2, ZNF207, RBBP5, WT1, HOXB13, KDM1A, YY1, RELA, ZIC2, HIF1A, GATA3, KLF15, MAX, NRIP1, ZNF143, MTA1, KLF4, ZNF512, TCF7L2, TP53, PKNOX1, MYOD1, EGR2, T, ELF3, AR, ZNF366, ZBTB26, NCOR1, BRD4, JUND, AHR
  • Target gene symbol (double-evidenced CRMs): GET1,GET1-SH3BGR,B3GALT5,BRWD1,PSMG1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 36
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000183527, ENSG00000185658, ENSG00000285815, ENSG00000182093, ENSG00000183778,
  • Related loop: chr21:39175000-39200000~~chr21:39625000-39650000, chr21:39375000-39400000~~chr21:39625000-39650000, chr21:39525000-39550000~~chr21:39625000-39650000, chr21:39625000-39650000~~chr21:41650000-41675000, chr21:39625000-39650000~~chr21:42975000-43000000, chr21:39633375-39634630~~chr21:39715081-39716789,
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