- Basic information
- CohesinDB ID: CDBP00419563
- Locus: chr21-39647406-39650769
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Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, GSE68388, GSE165895
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Cell type: RPE, Fibroblast, HCT-116, RT-112, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 31%,
"5_TxWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOSL1, ZFX, SMAD3, ZBTB48, FOXA1, DDX5, MLL4, HOXC5, RELA, ETS1, MYC, CTCFL, CHD7, PRDM1, DAXX, HIF1A, PBX4, PROX1, OTX2, STAT3, MAX, TAL1, FOS, CEBPB, KLF6, ETV1, KDM5B, TP53, BMPR1A, GRHL2, JUN, ELF3, ZHX2, BRD2, SPI1, RNF2, BRD4, E2F1, MAZ, TEAD4, FOSL2
- Target gene symbol (double-evidenced CRMs): BRWD1,GET1,B3GALT5,GET1-SH3BGR,PSMG1
- Function elements
- Human SNPs: Alcohol_dependence
- Number of somatic mutations (coding): 40
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000183527,
ENSG00000185658,
ENSG00000285815,
ENSG00000182093,
ENSG00000183778,
- Related loop:
chr21:39175000-39200000~~chr21:39625000-39650000,
chr21:39175000-39200000~~chr21:39650000-39675000,
chr21:39375000-39400000~~chr21:39625000-39650000,
chr21:39525000-39550000~~chr21:39625000-39650000,
chr21:39625000-39650000~~chr21:41650000-41675000,
chr21:39625000-39650000~~chr21:42975000-43000000,
chr21:39650000-39675000~~chr21:39750000-39775000,
chr21:39650000-39675000~~chr21:40925000-40950000,