- Basic information
- CohesinDB ID: CDBP00419574
- Locus: chr21-39675580-39677043
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BLY, GSE105028, GSE25021, ENCSR917QNE, GSE115602, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR703TNG, GSE116344, GSE145327, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR981FDC, GSE206145, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, GSE111913, GSE83726, GSE50893, ENCSR748MVX
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, RH4, HEK293T, HEKn, GM2610, SLK, A-549, GM2588, HUES64, SK-N-SH, RT-112, Liver, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 17% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.800
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
69% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"7_Enh": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, XBP1, HNF1A, FOXA1, HLF, SUZ12, ZNF90, ATF3, NFIC, RUNX3, CHD7, WDHD1, SMARCE1, PAX5, TP63, MITF, KLF5, TEAD1, TRIM28, KLF6, ETV1, ESR1, HNF1B, PITX3, USF2, CTCF, JUN, TCF12, EP300, BAF155, MNT, SOX5, RYBP, DPF2, E2F6, IRF4, PRKDC, E2F1, TEAD4, FOXA3, ZNF175, PDX1, TFAP2C, RBPJ, EED, POU2F2, CHD8, MYCN, POU5F1, BRD3, CTBP1, MTA2, DUX4, ZBTB48, STAT1, SRF, SAP130, TBP, ERG, HOXC5, ASCL1, OGG1, NFKB2, ETS1, MYC, SMARCA4, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, IKZF1, RCOR1, NR3C1, ESRRA, CEBPB, CREB1, EZH2, GRHL2, EBF3, ZHX2, SPI1, EHF, ZNF257, IRF1, PCBP1, HDAC2, GATA2, GATAD2B, SIX2, MXI1, RELB, NCOA2, PTBP1, RUNX1, CBX1, BCL6, SMC1A, EZH2phosphoT487, NKX2-2, SIN3A, ZFX, SOX13, SMAD3, TET2, ERG3, SMARCC1, CREBBP, ZXDC, NOTCH1, RUNX2, GATA4, ARNT, ZNF48, PBX3, MAFB, FOS, MED1, ZEB1, SCRT2, PIAS1, SETDB1, TBX5, USF1, SP1, BCL11A, GSPT2, HNF4A, TFAP2A, NKX2-5, REST, ARID1A, POU2F3, ASH2L, CTBP2, TCF3, FOXP1, AATF, SMC3, STAG1, MLLT1, PAX7, TRP47, CBFA2T2, MEF2B, FOXA2, EBF1, CHD2, WT1, FOXF1, TCF7, CDK9, KDM1A, YY1, RELA, JUNB, ISL1, SP140, TCF4, HIF1A, SKIL, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, HAND2, PLAG1, CBX2, KLF4, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, ZNF687, PKNOX1, TP53, ZNF334, NFKB1, MYOD1, EGR2, PHOX2B, ELF3, TBX21, BHLHE40, AR, PAX3-FOXO1, EGLN2, MAML3, HEXIM1, HSF1, ZBTB26, NOTCH3, BRD4, SCRT1, IKZF2, CLOCK, JUND, MAZ, TBX2, AHR
- Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,B3GALT5,SH3BGR
- Function elements
- Human SNPs: Corneal_astigmatism
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 10
- Related genes and loops