- Basic information
- CohesinDB ID: CDBP00419619
- Locus: chr21-39864542-39868722
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 64% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.233
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
48% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 38%,
"14_ReprPCWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PAX3-FOXO1, GLIS1, ZSCAN5D, ZNF263, MYCN, MYC, ZFX, SP140, POU4F2, T, DUX4, ZBTB48, WT1, ZIC2, TET2, ERG3, CTCF, NRIP1, STAG1
- Target gene symbol (double-evidenced CRMs): PCP4,GET1-SH3BGR,B3GALT5,SH3BGR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 18
- Number of somatic mutations (non-coding): 19
- Related genes and loops
- Related gene:
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
- Related loop:
chr21:38850000-38875000~~chr21:39850000-39875000,
chr21:39500000-39525000~~chr21:39850000-39875000,
chr21:39600000-39625000~~chr21:39850000-39875000,
chr21:39787253-39789571~~chr21:39866317-39868146,
chr21:39850000-39875000~~chr21:40050000-40075000,
chr21:39850000-39875000~~chr21:40100000-40125000,
chr21:39850000-39875000~~chr21:40125000-40150000,
chr21:39850000-39875000~~chr21:40275000-40300000,
chr21:39850000-39875000~~chr21:40375000-40400000,
chr21:39866128-39868467~~chr21:40119863-40122093,
chr21:39866153-39868505~~chr21:40120196-40122032,
chr21:39866192-39868418~~chr21:40119606-40122062,
chr21:39866204-39868182~~chr21:40119842-40122098,
chr21:39866213-39868462~~chr21:40120304-40121958,
chr21:39866223-39868177~~chr21:40120108-40122096,
chr21:39866253-39868184~~chr21:40120212-40121973,
chr21:39866275-39868439~~chr21:40119552-40122087,
chr21:39866285-39868187~~chr21:40120420-40122028,
chr21:39866287-39868162~~chr21:40120151-40122075,
chr21:39866296-39868156~~chr21:40119861-40122095,
chr21:39866307-39868195~~chr21:40120272-40122048,
chr21:39866353-39868186~~chr21:40120101-40122033,
chr21:39866375-39868193~~chr21:40120236-40122026,
chr21:39866435-39868216~~chr21:40120098-40121959,
chr21:39866538-39868625~~chr21:40120093-40122096,
chr21:39866598-39868148~~chr21:40120301-40121901,
chr21:39866650-39867964~~chr21:40120464-40121810,
chr21:39866655-39868186~~chr21:40120401-40121860,
chr21:39866691-39868175~~chr21:40120100-40122051,
chr21:39866701-39868153~~chr21:40120452-40121717,
chr21:39866710-39868154~~chr21:40120460-40121701,
chr21:39866742-39867981~~chr21:40120389-40121831,