- Basic information
- CohesinDB ID: CDBP00419630
- Locus: chr21-39908275-39908862
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Data sourse: ENCSR000BLD, ENCSR000BTQ, GSE206145-GSE177045, GSE67783, ENCSR000BKV, GSE72082, GSE25021, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, ENCSR703TNG, GSE131606, GSE145327, GSE97394, GSE115602
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Cell type: MCF-7, H1-hESC, Fibroblast, DKO, HUES64, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
48% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 68%,
"14_ReprPCWk": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, EZH2phosphoT487, POU2F2, CBX1, SMC1A, ZSCAN5D, MYCN, ZNF263, BRD1, PGR, ZFX, TEAD4, POU5F1, FOXA2, WT1, ZBTB48, SMAD3, FOXA1, XBP1, TET2, ERG3, SUZ12, DDX5, ERG2, CDK9, ZFHX2, YY1, RELA, CREBBP, ATF3, MYC, CDK6, CTCFL, RAD21, SP140, HIF1A, ZNF444, SMARCE1, MAX, TP63, ZNF143, MED1, TEAD1, TRIM28, NR2F1, EZH2, ZNF217, ESR1, ZNF687, CHD8, ZNF334, EGR2, CTCF, SPI1, NIPBL, TFAP2A, AR, EGLN2, FLI1, HSF1, NOTCH3, BRD4, MAZ, SMC3, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): PCP4,B3GALT5,SH3BGR,MX1,GET1-SH3BGR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 10
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
ENSG00000157601,
- Related loop:
chr21:39500000-39525000~~chr21:39900000-39925000,
chr21:39517315-39519547~~chr21:39910639-39912376,
chr21:39600000-39625000~~chr21:39900000-39925000,
chr21:39750000-39775000~~chr21:39900000-39925000,
chr21:39775000-39800000~~chr21:39900000-39925000,
chr21:39787215-39789565~~chr21:39910588-39912275,
chr21:39787253-39789571~~chr21:39910500-39912317,
chr21:39787296-39789560~~chr21:39910501-39912411,
chr21:39787332-39789505~~chr21:39910608-39912279,
chr21:39787705-39789776~~chr21:39910608-39912422,
chr21:39900000-39925000~~chr21:40100000-40125000,
chr21:39900000-39925000~~chr21:40375000-40400000,
chr21:39900000-39925000~~chr21:41425000-41450000,
chr21:39907747-39909282~~chr21:40119552-40122087,