- Basic information
- CohesinDB ID: CDBP00419631
- Locus: chr21-39909863-39913124
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000EGW, GSE105028, GSE131606, GSE25021, GSE115602, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE76893, GSE51234, GSE206145-NatGen2015, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, ENCSR879KXD, ENCSR000ECE, ENCSR000EHX, ENCSR767DFK, GSE97394, ENCSR000BTQ, GSE105004, ENCSR853VWZ, GSE129526, GSE111913, ENCSR335RKQ, GSE68388, GSE83726, GSE126990, GSE50893
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Cell type: RH4, GM2610, SLK, CVB-hiPSC, GP5d, HuCC-T1, H9-hESC, GM2630, Fibroblast, Ishikawa, GM12890, K-562, DKO, H1-hESC, GM2588, SK-N-SH, RT-112, HUES64, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Neurons-H1, A-549, HeLa, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
48% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 69%,
"14_ReprPCWk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, EZH2phosphoT487, POU2F2, CBX1, SMC1A, ZSCAN5D, MYCN, ZNF263, BRD1, PGR, ZFX, TEAD4, POU5F1, FOXA2, WT1, ZBTB48, SMAD3, FOXA1, XBP1, TET2, ERG3, SUZ12, DDX5, ERG2, CDK9, ZFHX2, YY1, RELA, CREBBP, ATF3, MYC, CDK6, CTCFL, RAD21, SP140, HIF1A, ZNF444, SMARCE1, MAX, TP63, ZNF143, MED1, TEAD1, TRIM28, NR2F1, EZH2, ZNF217, ESR1, ZNF687, CHD8, ZNF334, EGR2, CTCF, SPI1, NIPBL, TFAP2A, AR, EGLN2, FLI1, HSF1, NOTCH3, BRD4, MAZ, SMC3, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): SH3BGR,MX1,PCP4,B3GALT5,GET1-SH3BGR
- Function elements
- Human SNPs: Venlafaxine_response_in_generalised_anxiety_disorder_(responders_vs_non-responders_after_12_weeks)
- Number of somatic mutations (coding): 23
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
ENSG00000157601,
- Related loop:
chr21:39500000-39525000~~chr21:39900000-39925000,
chr21:39517315-39519547~~chr21:39910639-39912376,
chr21:39600000-39625000~~chr21:39900000-39925000,
chr21:39750000-39775000~~chr21:39900000-39925000,
chr21:39775000-39800000~~chr21:39900000-39925000,
chr21:39787215-39789565~~chr21:39910588-39912275,
chr21:39787253-39789571~~chr21:39910500-39912317,
chr21:39787296-39789560~~chr21:39910501-39912411,
chr21:39787332-39789505~~chr21:39910608-39912279,
chr21:39787705-39789776~~chr21:39910608-39912422,
chr21:39900000-39925000~~chr21:40100000-40125000,
chr21:39900000-39925000~~chr21:40375000-40400000,
chr21:39900000-39925000~~chr21:41425000-41450000,
chr21:39907747-39909282~~chr21:40119552-40122087,