- Basic information
- CohesinDB ID: CDBP00419661
- Locus: chr21-40053259-40055664
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Data sourse: ENCSR000BTQ, ENCSR000BTU, GSE206145-GSE177045, GSE67783, GSE72082, GSE111913, GSE76893, GSE206145, GSE206145-NatGen2015, GSE68388, ENCSR703TNG, GSE25021, GSE115602
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Cell type: MCF-7, Fibroblast, HEK293T, Ishikawa, RT-112, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
38% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 53%,
"7_Enh": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, FOXA1, HLF, SUZ12, MLL4, TFAP4, NFIC, SMARCE1, CDX2, KLF5, TEAD1, ELF1, SNAI2, ZNF217, ESR1, LMO2, PITX3, CTCF, TCF12, JUN, BAF155, EP300, MNT, ZNF302, DPF2, PRKDC, E2F1, NR5A2, TEAD4, PDX1, RBPJ, TFAP2C, GLIS1, MYCN, CTBP1, ZBTB48, SRF, ERG, ASCL1, MYC, RFX1, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, NKX3-1, VDR, NR3C1, ESRRA, CEBPB, CREB1, EZH2, GRHL2, TRPS1, ZHX2, HDAC2, GATA2, HCFC1, NCOA2, RUNX1, CTNNB1, CBX1, SMC1A, NKX2-2, SIN3A, ZFX, TET2, CREBBP, ZXDC, NOTCH1, RUNX2, OSR2, ARNT, NFIB, NRF1, FOXM1, MAFB, FOS, MED1, PML, MYB, SCRT2, PIAS1, KLF9, NCOA1, SETDB1, USF1, NIPBL, TFAP2A, BCL11A, HNF4A, NKX2-5, ASH2L, CTBP2, TCF3, FOXP1, MBD2, SMC3, STAG1, FOXA2, WT1, FOXF1, CDK9, HOXB13, KDM1A, YY1, RELA, TCF4, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, HAND2, CBX2, NCOA3, NR2F2, TCF7L2, KDM5B, ZNF687, TP53, PKNOX1, ZSCAN22, ARRB1, AR, PAX3-FOXO1, RXR, EGLN2, ZNF366, ZBTB42, RB1, NOTCH3, BRD4, SCRT1, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): PCP4,SH3BGR,GET1-SH3BGR,B3GALT5
- Function elements
- Human SNPs: Body_mass_index
- Number of somatic mutations (coding): 38
- Number of somatic mutations (non-coding): 0
- Related genes and loops