- Basic information
- CohesinDB ID: CDBP00419665
- Locus: chr21-40070140-40071348
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Data sourse: GSE72082, GSE98367, GSE76893, GSE120943, ENCSR703TNG, GSE25021
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Cell type: MCF-7, Monocytes, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: NIPBL,SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
38% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 74%,
"14_ReprPCWk": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, PGR, FOXA1, MLL4, HNRNPK, TFAP4, WDHD1, SMARCE1, CDX2, TEAD1, ZNF217, ESR1, JUN, TCF12, BAF155, EP300, MNT, DPF2, PAX8, TEAD4, TFAP2C, CTBP1, ZNF317, ERG, OGG1, MYC, RAD21, GRHL3, PROX1, NKX3-1, NR3C1, CEBPB, ESRRA, CREB1, EZH2, GRHL2, ZHX2, HDAC2, GATA2, GATAD2B, NCOA2, CTNNB1, CBX1, SIN3A, ZXDC, CREBBP, ARNT, NFIB, ETV6, FOXM1, FOS, MED1, PIAS1, NCOA1, NIPBL, ATF7, ASH2L, CTBP2, MBD2, HOXB13, RELA, TARDBP, NEUROD1, HIF1A, GATA3, MAX, NRIP1, ZNF143, CEBPG, NCOA3, NR2F2, TCF7L2, NR2F1, ZNF687, TP53, AR, ZNF579, EGLN2, ZNF366, BRD4, JUND, CLOCK, CUX1, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,B3GALT5,SH3BGR,PCP4
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 8
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000285815,
ENSG00000185437,
ENSG00000183778,
ENSG00000183036,
- Related loop:
chr21:39500000-39525000~~chr21:40050000-40075000,
chr21:39525000-39550000~~chr21:40075000-40100000,
chr21:39600000-39625000~~chr21:40050000-40075000,
chr21:39600000-39625000~~chr21:40075000-40100000,
chr21:39775000-39800000~~chr21:40075000-40100000,
chr21:39850000-39875000~~chr21:40050000-40075000,
chr21:39975000-40000000~~chr21:40075000-40100000,
chr21:40075000-40100000~~chr21:40300000-40325000,