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Basic information

CohesinDB ID: CDBP00419675

Locus: chr21-40116723-40123569

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, H1-hESC, SNYDER, Leukemia-SEM, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, HeLa-Tet-On, RT-112, THP-1, GM19099, HUES64, MCF-7, GM12892, T-47D, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 60% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.311

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 38% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 73%, "14_ReprPCWk": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, FOXA2, ZFX, XBP1, FOXA1, DDX5, ERG, RELA, CREBBP, ZNF384, ARNT, GATA3, GABPA, MAFB, NKX3-1, GATA1, FOS, NCOA3, ZNF264, CREB1, EZH2, ESR1, NCOA1, ZNF334, AR, GATA2, ZNF766, GTF2F1, PDX1, FOSL2

Target gene symbol (double-evidenced CRMs): GET1-SH3BGR,SH3BGR,PCP4,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 86

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000285815, ENSG00000185437, ENSG00000183778, ENSG00000183036,

eachgene

Deatailed information for cohesin site CDBP00419675