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Basic information

CohesinDB ID: CDBP00419844

Locus: chr21-40844770-40847676

Data sourse: ENCSR000BLD, GSE67783, GSE86191, GSE98367, GSE111913, ENCSR404BPV, GSE105028, GSE85526, ENCSR000ECE, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE206145, GSE145327, GSE97394, GSE165895

Cell type: RPE, H1-hESC, Fibroblast, HCT-116, Monocytes, HEKn, Neurons-H1, HUES64, HSPC, RT-112, HFFc6, Macrophage, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 37% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 27%, "14_ReprPCWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, TRIM25, SOX2, FOXA1, SUZ12, RING1B, ATF3, ZFP64, CHD7, MORC2, CBFB, SMARCE1, TP63, ZSCAN4, TEAD1, TRIM28, SNAI2, SAP30, ESR1, OCA2, JUN, TCF12, CTCF, EP300, BAF155, RYBP, E2F6, TRIM24, E2F1, TEAD4, PDX1, TFAP2C, JARID2, NANOG, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, ZBTB17, ZBTB48, TBP, ERG, ZBTB21, ASCL1, OGG1, MYC, SMARCA4, KDM4A, RAD21, LHX2, GRHL3, STAT3, NKX3-1, NR3C1, CREB1, EZH2, ZHX2, EHF, HDAC2, GATA2, MXI1, RUNX1, SMC1A, EZH2phosphoT487, NKX2-2, SIRT6, SIN3A, ZFX, SMAD3, ERG3, CBX8, RARA, PBX4, NRF1, ATF2, MAFB, FOS, CHD1, ZEB1, SCRT2, C11orf30, SETDB1, MAFK, BCL11A, USF1, REST, ATF7, POU2F3, ASH2L, ZNF605, CTBP2, HNRNPLL, BCOR, MBD2, FOXP1, AATF, SMC3, STAG1, TRP47, FOXA2, RBBP5, MAFF, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, SP140, PCGF1, TAL1, MAX, ZNF143, ZNF791, KDM5B, TP53, NFKB1, BRD2, AR, TAF1, HEXIM1, TFIIIC, HSF1, ZBTB26, RNF2, BRD4, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): .

Function elements

Human SNPs: Tuberculosis

Number of somatic mutations (coding): 33

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene:

eachgene

Deatailed information for cohesin site CDBP00419844