- Basic information
- CohesinDB ID: CDBP00419845
- Locus: chr21-40847889-40848496
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Data sourse: ENCSR000BLD, ENCSR000BTQ, GSE67783, GSE72082, GSE86191, GSE25021, ENCSR404BPV, GSE105028, GSE206145, ENCSR000ECE, ENCSR198ZYJ, ENCSR703TNG, GSE131606, GSE145327, GSE97394
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Cell type: MCF-7, H1-hESC, RPE, HCT-116, Neurons-H1, DKO, HUES64, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SMC3,Rad21,SA1,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
37% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"13_ReprPC": 33%,
"14_ReprPCWk": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, CBFA2T2, CBX1, POU2F2, BRD1, POU5F1, MYCN, ZNF263, ZFX, TEAD4, XBP1, ZBTB48, SMAD3, WT1, FOXA1, ZSCAN5A, TET2, ERG3, ERG, YY1, RELA, KDM1A, OGG1, MYC, RAD21, SP140, ARNT, HIF1A, GRHL3, PRDM9, STAT3, MAX, TP63, ZNF143, MITF, MED1, SCRT2, NR2F1, EZH2, ESR1, SETDB1, CTCF, USF1, SPI1, RXR, E2F6, MXD3, FLI1, HSF1, SCRT1, CLOCK, AATF, SMC3, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
- Related loop:
chr21:40125000-40150000~~chr21:40825000-40850000,
chr21:40143196-40145254~~chr21:40841232-40842970,
chr21:40143235-40145160~~chr21:40841024-40843128,
chr21:40143263-40145135~~chr21:40841259-40842961,
chr21:40150000-40175000~~chr21:40825000-40850000,
chr21:40450000-40475000~~chr21:40825000-40850000,
chr21:40450000-40475000~~chr21:40850000-40875000,
chr21:40465557-40467899~~chr21:40840912-40842965,
chr21:40465667-40468011~~chr21:40840995-40843250,
chr21:40465872-40468080~~chr21:40840988-40842938,
chr21:40466129-40468033~~chr21:40841024-40843128,
chr21:40466131-40467839~~chr21:40840989-40842899,
chr21:40466218-40467881~~chr21:40841049-40843350,
chr21:40466465-40467826~~chr21:40840980-40842929,
chr21:40475000-40500000~~chr21:40825000-40850000,
chr21:40504438-40505740~~chr21:40840988-40842938,
chr21:40525000-40550000~~chr21:40825000-40850000,
chr21:40575000-40600000~~chr21:40825000-40850000,
chr21:40700000-40725000~~chr21:40825000-40850000,
chr21:40825000-40850000~~chr21:41025000-41050000,
chr21:40825000-40850000~~chr21:41050000-41075000,
chr21:40840980-40842929~~chr21:41068151-41070172,
chr21:40841049-40843350~~chr21:41006848-41008091,
chr21:40841049-40843350~~chr21:41044725-41047059,
chr21:40841049-40843350~~chr21:41068068-41070387,
chr21:40841259-40842961~~chr21:41068059-41070218,
chr21:40841274-40842934~~chr21:41068185-41070081,
chr21:40846553-40848837~~chr21:41044731-41046662,
chr21:40846553-40848837~~chr21:41068042-41070202,
chr21:40846588-40848800~~chr21:41044806-41046966,
chr21:40846588-40848800~~chr21:41068046-41070192,
chr21:40850000-40875000~~chr21:40950000-40975000,
chr21:40850000-40875000~~chr21:41025000-41050000,
chr21:40850000-40875000~~chr21:41050000-41075000,
chr21:40850000-40875000~~chr21:41075000-41100000,