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Basic information

CohesinDB ID: CDBP00419880

Locus: chr21-41023461-41025283

Data sourse: ENCSR000BTQ, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, ENCSR198ZYJ, ENCSR703TNG, GSE25021, GSE115602

Cell type: MCF-7, Neurons-H1, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 57%, "14_ReprPCWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, BMI1, CHD7, SMARCE1, MITF, TEAD1, ZNF217, ESR1, CTCF, TCF12, BAF155, EP300, MNT, DPF2, IRF4, RFX5, E2F1, NR5A2, TEAD4, PDX1, TFAP2C, POU2F2, CHD8, MYCN, POU5F1, KDM4C, CTBP1, ZBTB17, ZBTB48, ZNF300, ERG, MYC, SMARCA4, RFX1, RAD21, GRHL3, NKX3-1, VDR, NR3C1, CEBPB, ESRRA, EZH2, GRHL2, TRPS1, HDAC2, GATA2, GATAD2B, NCOA2, CBX1, NKX2-2, SIN3A, ZFX, POU4F2, CREBBP, ZXDC, CDK6, GR, ARNT, MAFB, MED1, NCOA1, USF1, TFAP2A, CTBP2, MBD2, SMC3, STAG1, FOXA2, RELA, TARDBP, HIF1A, GATA3, NRIP1, ZNF143, TLE3, NCOA3, NR2F2, NR2F1, KDM5B, ZNF687, PKNOX1, ARRB1, AR, YAP1, EGLN2, NCOR1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): MX1,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000183778, ENSG00000157601,

eachgene

Deatailed information for cohesin site CDBP00419880