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Basic information

CohesinDB ID: CDBP00419888

Locus: chr21-41045041-41047309

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE115602, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE76893, GSE51234, GSE206145-NatGen2015, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE145327, ENCSR000EEG, ENCSR000BLS, GSE85526, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE55407, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, GSE68388, GSE83726, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM2610, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, GM2630, Fibroblast, HEKn, HeLa-S3, K-562, DKO, H1-hESC, GM2588, SK-N-SH, RT-112, THP-1, HUES64, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 22% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.667

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 48%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, PGR, SOX2, XBP1, FOXA1, SFMBT1, ZNF90, NFIC, ZNF444, HDAC3, TEAD1, TRIM28, RBM39, SNAI2, ZNF217, ESR1, CTCF, BAF155, EP300, GATA6, IRF4, E2F1, ZNF528, TEAD4, PDX1, TFAP2C, EED, GLIS1, POU2F2, CHD8, NANOG, MYCN, POU5F1, TOP2A, ZNF263, ERF, ZBTB17, ZBTB48, SRF, HNF4G, ERG, ASCL1, MYC, RAD21, GRHL3, GABPA, XRCC5, NKX3-1, NR3C1, CEBPB, EZH2, ZHX2, SPI1, HDAC2, GATA2, FLI1, NCOA2, RUNX1, CBX1, SMC1A, NKX2-2, SOX13, ZFX, SMAD3, ZNF770, ERG3, ZNF654, TRIM22, PRDM10, CREBBP, ZNF384, GR, ARNT, NFIB, ATF2, MAFB, MED1, SCRT2, PIAS1, SMAD1, REST, ARID1A, ASH2L, BCOR, FOXP1, SMC3, STAG1, NFATC3, TBL1X, FOXA2, WT1, HOXB13, ZNF580, YY1, RELA, BRG1, HIF1A, GATA3, MAX, NRIP1, ZNF143, TLE3, NCOA3, KDM5B, TP53, PKNOX1, ZNF334, BRD2, ARRB1, AR, TAF1, EGLN2, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): .

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene:

eachgene

Deatailed information for cohesin site CDBP00419888