- Basic information
- CohesinDB ID: CDBP00419891
- Locus: chr21-41066434-41072173
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 77% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.133
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 28%,
"15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: LCORL, NME2, FOXA1, SUZ12, ZBTB7B, HDGF, BMI1, TP63, ZSCAN4, TRIM28, BCLAF1, ETV1, NFE2L2, LMO2, PITX3, CTCF, TCF12, EP300, BAF155, MNT, SOX6, TEAD4, MYCN, POU5F1, CTBP1, ZNF317, ZBTB48, NONO, DDX5, MYC, SMARCA4, ARID1B, GRHL3, NKX2-1, FOXK2, IKZF1, RCOR1, NFE2, ESRRA, CREB1, EBF3, GATA2, ZSCAN29, MXI1, RUNX1, MAFG, HDAC1, LDB1, ZFX, TET2, NFIB, PRDM9, HMBOX1, PBX3, CBFA2T3, PML, CEBPD, PIAS1, C11orf30, FOXP1, MLLT1, TRP47, CBFA2T2, FOXA2, MTA3, CHD2, WT1, MAFF, ZKSCAN1, KDM1A, RELA, TARDBP, AHR, SP140, TCF4, GATA3, TAL1, MAX, GATA1, HAND2, NCOA3, ZNF791, ZNF334, PHOX2B, ARRB1, PAX3-FOXO1, AR, MAML3, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 54
- Related genes and loops
- Related gene:
- Related loop:
chr21:39500000-39525000~~chr21:41075000-41100000,
chr21:39600000-39625000~~chr21:41075000-41100000,
chr21:40125000-40150000~~chr21:41050000-41075000,
chr21:40125000-40150000~~chr21:41075000-41100000,
chr21:40142884-40144840~~chr21:41068233-41070192,
chr21:40143203-40144858~~chr21:41068086-41070092,
chr21:40143209-40145089~~chr21:41068098-41070028,
chr21:40143211-40145650~~chr21:41070818-41072228,
chr21:40143216-40145182~~chr21:41068067-41070302,
chr21:40143218-40145094~~chr21:41068097-41070414,
chr21:40143220-40145191~~chr21:41068083-41070648,
chr21:40143223-40145165~~chr21:41068145-41070397,
chr21:40143235-40145160~~chr21:41068042-41070202,
chr21:40143238-40145160~~chr21:41068059-41070286,
chr21:40143239-40145147~~chr21:41068073-41070024,
chr21:40143249-40145199~~chr21:41068260-41070064,
chr21:40143262-40144895~~chr21:41068445-41069912,
chr21:40143263-40145135~~chr21:41068059-41070218,
chr21:40143267-40144892~~chr21:41068032-41070376,
chr21:40143268-40144900~~chr21:41068052-41070078,
chr21:40143275-40144996~~chr21:41070881-41072256,
chr21:40143276-40145164~~chr21:41068061-41070317,
chr21:40143283-40145087~~chr21:41068113-41070021,
chr21:40143287-40145205~~chr21:41068185-41070081,
chr21:40143288-40144975~~chr21:41068410-41069966,
chr21:40143291-40145135~~chr21:41068238-41070028,
chr21:40143292-40144823~~chr21:41068564-41069996,
chr21:40143311-40145530~~chr21:41068080-41070453,
chr21:40143361-40144725~~chr21:41068534-41069892,
chr21:40143368-40144757~~chr21:41068035-41070009,
chr21:40143375-40144769~~chr21:41068498-41069899,
chr21:40143388-40144776~~chr21:41068509-41069855,
chr21:40150000-40175000~~chr21:41050000-41075000,
chr21:40150000-40175000~~chr21:41075000-41100000,
chr21:40175000-40200000~~chr21:41075000-41100000,
chr21:40425000-40450000~~chr21:41075000-41100000,
chr21:40450000-40475000~~chr21:41050000-41075000,
chr21:40450000-40475000~~chr21:41075000-41100000,
chr21:40465557-40467899~~chr21:41068145-41070397,
chr21:40465667-40468011~~chr21:41068097-41070414,
chr21:40466218-40467881~~chr21:41068068-41070387,
chr21:40466299-40467874~~chr21:41068067-41070302,
chr21:40466473-40467959~~chr21:41068059-41070218,
chr21:40466509-40467846~~chr21:41068098-41070028,
chr21:40475000-40500000~~chr21:41075000-41100000,
chr21:40511954-40513659~~chr21:41068067-41070302,
chr21:40525000-40550000~~chr21:41050000-41075000,
chr21:40575000-40600000~~chr21:41050000-41075000,
chr21:40625000-40650000~~chr21:41075000-41100000,
chr21:40650000-40675000~~chr21:41075000-41100000,
chr21:40700000-40725000~~chr21:41050000-41075000,
chr21:40718539-40720597~~chr21:41068151-41070181,
chr21:40718930-40720732~~chr21:41068068-41070387,
chr21:40718939-40720561~~chr21:41068151-41070172,
chr21:40718992-40720551~~chr21:41068042-41070202,
chr21:40719048-40720726~~chr21:41068096-41070184,
chr21:40719112-40720557~~chr21:41068059-41070218,
chr21:40719112-40720557~~chr21:41070922-41072244,
chr21:40719160-40720470~~chr21:41071015-41072298,
chr21:40719251-40720453~~chr21:41070979-41072230,
chr21:40725000-40750000~~chr21:41050000-41075000,
chr21:40775000-40800000~~chr21:41075000-41100000,
chr21:40825000-40850000~~chr21:41050000-41075000,
chr21:40840980-40842929~~chr21:41068151-41070172,
chr21:40841049-40843350~~chr21:41068068-41070387,
chr21:40841136-40842853~~chr21:41070891-41072415,
chr21:40841259-40842961~~chr21:41068059-41070218,
chr21:40841274-40842934~~chr21:41068185-41070081,
chr21:40846553-40848837~~chr21:41068042-41070202,
chr21:40846588-40848800~~chr21:41068046-41070192,
chr21:40850000-40875000~~chr21:41050000-41075000,
chr21:40850000-40875000~~chr21:41075000-41100000,
chr21:40900000-40925000~~chr21:41050000-41075000,
chr21:40925000-40950000~~chr21:41050000-41075000,
chr21:40925000-40950000~~chr21:41075000-41100000,
chr21:41075000-41100000~~chr21:41175000-41200000,