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Basic information

CohesinDB ID: CDBP00419892

Locus: chr21-41075452-41076905

Data sourse: GSE206145-NatGen2015, GSE111913, GSE67783, GSE86191

Cell type: RT-112, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 55%, "14_ReprPCWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, MAFG, CHD8, FOXA2, MYCN, TBL1X, ZSCAN5D, POU5F1, ZFX, ZNF534, XBP1, MAFF, ZBTB48, WT1, ZSCAN5A, SUZ12, ERG, YY1, RELA, OGG1, ATF3, MYC, SP140, GRHL3, CBFB, PRDM9, STAT3, MAX, NCAPH2, ZNF143, CEBPB, TRIM28, ZNF680, NR2F1, EZH2, ESR1, OCA2, C11orf30, ZNF334, CTCF, JUN, MAFK, AR, RXR, REST, GATA2, E2F6, FLI1, HSF1, TFIIIC, NOTCH3, BRD4, MAZ, HCFC1R1, AATF, SMC3, STAG1, ZNF316

Target gene symbol (double-evidenced CRMs): B3GALT5,SH3BGR,BACE2,GET1-SH3BGR

Function elements

Human SNPs: Hip_circumference_adjusted_for_BMI

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000285815, ENSG00000185437, ENSG00000183778, ENSG00000182240,

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Deatailed information for cohesin site CDBP00419892