Deatailed information for cohesin site CDBP00419920

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  • Basic information
  • CohesinDB ID: CDBP00419920
  • Locus: chr21-41166931-41172082
  • Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, ENCSR703TNG, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, THP-1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 60% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.333
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 67% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "1_TssA": 16%, "7_Enh": 15%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, MLL4, ZBTB7B, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF586, TEAD1, ZNF121, LMO2, OCA2, HDAC8, ZNF561, PAX8, E2F4, KMT2B, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ZMYND11, DUX4, STAT1, ERG, ZBTB8A, EZH1, SMARCA4, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, KLF17, ZNF257, GATA2, MXD3, FLI1, HCFC1, MXI1, RUNX1, NKX2-2, TRIM22, SMARCC1, PRDM10, ZBTB2, ZBTB10, ATF2, FOXM1, SP2, PIAS1, SMAD1, NR1H2, RBM25, ELL2, HMGB1, NFATC3, CBFA2T2, CREM, CHD2, NFATC1, SS18, PAF1, ZSCAN16, WT1, JUNB, NEUROD1, TCF4, ZFP36, PLAG1, KLF4, ZFP69B, BCL11B, ZBTB6, BCL6B, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, HSF1, NCOR1, ZBTB26, ILF3, FOSL1, ZNF660, XBP1, ZNF596, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, MAF, ELF1, RBM39, SNAI2, KLF10, FUS, CTCF, JUN, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, IRF4, ZNF677, PDX1, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, SRF, DDX5, ONECUT1, KDM4A, RXRA, NKX3-1, PRDM14, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, KDM5A, ZBTB14, SMARCA5, CTNNB1, EZH2phosphoT487, AFF4, SOX13, ZNF770, ZNF513, ZNF18, SP3, ARNT, NFIB, DAXX, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, KLF9, TBX5, ZNF37A, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, ZNF468, PGR, FANCL, ZNF496, PATZ1, RING1B, TFAP4, CHD7, ZNF444, ATF4, ZNF189, SMARCE1, MZF1, KLF6, ZNF217, ESR1, SAP30, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, STAT3, IKZF1, INO80, EZH2, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF777, ZNF490, ZNF76, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ERG3, CREBBP, RARA, ZNF384, TAF15, SMAD4, CDK8, ZEB1, ZNF22, MAFK, REST, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, HDAC6, ZNF692, GTF2B, ZNF574, RELA, MAX, TCF7L2, NR2F1, KDM5B, ZNF791, ZNF547, MYOD1, AR, ZNF324, HEXIM1, AHR, FOSL2, MBD3, ZNF391, SUZ12, RBFOX2, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, HDAC3, CDX2, ZNF629, KLF5, TRIM28, ETV1, ZNF26, HNF1B, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, ZNF512B, E2F1, SMC1, TEAD4, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, EHF, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, PBX4, NRF1, FOS, CHD1, MED1, KDM6B, MYB, CEBPD, VEZF1, L3MBTL2, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, NELFA, FOXA2, RBBP5, ZNF600, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF213, ZNF843, BHLHE40, TAF1, ZBTB40, NOTCH3, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): BACE2,MX2,FAM3B,PRDM15,TMPRSS2,MX1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 171
  • Number of somatic mutations (non-coding): 68
  • Related genes and loops
  • Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000141956,
  • Related loop: chr21:40875000-40900000~~chr21:41175000-41200000, chr21:41075000-41100000~~chr21:41175000-41200000, chr21:41121260-41122868~~chr21:41167149-41169803, chr21:41150000-41175000~~chr21:41350000-41375000, chr21:41150000-41175000~~chr21:41425000-41450000, chr21:41150000-41175000~~chr21:41450000-41475000, chr21:41150000-41175000~~chr21:41775000-41800000, chr21:41167149-41169803~~chr21:41235512-41237477, chr21:41167199-41169386~~chr21:41250553-41252905, chr21:41169934-41171396~~chr21:41373764-41374984, chr21:41175000-41200000~~chr21:41275000-41300000, chr21:41175000-41200000~~chr21:41425000-41450000, chr21:41175000-41200000~~chr21:41750000-41775000, chr21:41175000-41200000~~chr21:41775000-41800000,
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