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Basic information

CohesinDB ID: CDBP00419925

Locus: chr21-41196787-41197468

Data sourse: GSE138405, GSE111913, GSE206145, GSE101921, GSE68388, GSE126990

Cell type: RPE, HMEC, Hela-Kyoto, MCF-10A, HCAEC, RT-112, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: Mau2,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 62%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GLIS1, PGR, BCL6, ZNF263, ZFX, ZSCAN21, HNF1A, ZBTB48, WT1, FOXA1, ZNF770, DDX5, ERG2, ZFHX2, PRDM10, KDM1A, ZNF384, JUNB, ATF3, MYC, NFIC, ZNF362, ZNF184, SP140, ARNT, ZIC2, HIF1A, ZNF189, TAL1, MAX, MAFB, ZNF449, FOS, RCOR1, ZNF639, MED1, ZNF629, SP7, GFI1B, ZNF121, ZNF573, SNAI2, ESR1, TP53, KLF8, HNF1B, GRHL2, SETDB1, EGR2, ZFP91, JUN, ELF3, KLF1, KLF17, IRF1, GATA2, IRF4, ZNF280D, BRD4, JUND, ZNF528, MAZ, ZSCAN23, STAG2, TFAP2C, FOSL2

Target gene symbol (double-evidenced CRMs): RIPK4,PRDM15,FAM3B,MX1,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 15

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000183421, ENSG00000141956,

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Deatailed information for cohesin site CDBP00419925