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Basic information

CohesinDB ID: CDBP00419926

Locus: chr21-41199133-41199869

Data sourse: GSE67783, GSE86191, GSE72082, GSE206145, GSE206145-NatGen2015

Cell type: MCF-7, RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 56%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, PGR, ZSCAN5D, MYCN, KDM4C, ZFX, WT1, ZBTB48, TET2, YY1, SP140, GRHL3, TP63, NR2F1, KDM5B, ESR1, BMPR1A, CTCF, HSF1, BRD4, MAZ, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): MX1,RIPK4,PRDM15,BACE2,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000183421, ENSG00000141956,

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Deatailed information for cohesin site CDBP00419926