- Basic information
- CohesinDB ID: CDBP00419929
- Locus: chr21-41207311-41209537
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Data sourse: GSE67783, GSE86191, GSE131956, GSE111913, GSE206145, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast, HCT-116, GBM39, RT-112, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 29%,
"15_Quies": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, XBP1, FOXA1, HLF, ATF3, NFIC, PRDM1, SMARCE1, MITF, KLF6, SNAI2, ESR1, OCA2, JUN, CTCF, TCF12, KLF1, PAX8, TEAD4, ZNF92, TFAP2C, RBPJ, POU2F2, CHD8, MYCN, ZNF263, ZBTB48, ASCL1, ETS1, SMARCA4, GRHL3, STAT3, XRCC5, APC, NFE2, DNMT3B, NR3C1, CEBPB, KMT2A, EZH2, FEZF1, ZHX2, IRF1, GATA2, MXI1, HCFC1R1, NFIL3, RUNX1, BCL6, CEBPA, LDB1, ZFX, TET2, PRDM10, CREBBP, RUNX2, NRF1, PBX4, NFIB, ARNT, PRDM9, CBFA2T3, FOS, MED1, CEBPD, SMAD1, SP1, BCL11A, ASH2L, SMC3, STAG1, CBFA2T2, TBL1X, ZNF692, WT1, HOXB13, YY1, RELA, JUNB, SP140, ZIC2, TAL1, MAX, ZNF143, GATA1, KLF4, CEBPG, NCOA3, NR2F2, NR2F1, TP53, NFKB1, BRD2, AR, HSF1, BRD4, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PDE9A,RSPH1,PRDM15,RIPK4,SLC37A1,C2CD2,MX1,UMODL1,BACE2,TMPRSS2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 42
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000157601,
ENSG00000184012,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:40900000-40925000~~chr21:41200000-41225000,
chr21:40925000-40950000~~chr21:41200000-41225000,
chr21:41121223-41122885~~chr21:41206719-41208416,
chr21:41200000-41225000~~chr21:41450000-41475000,
chr21:41200000-41225000~~chr21:41700000-41725000,
chr21:41200000-41225000~~chr21:41750000-41775000,
chr21:41200000-41225000~~chr21:41825000-41850000,
chr21:41200000-41225000~~chr21:41950000-41975000,
chr21:41200000-41225000~~chr21:42100000-42125000,
chr21:41200000-41225000~~chr21:42475000-42500000,
chr21:41200000-41225000~~chr21:42650000-42675000,