- Basic information
- CohesinDB ID: CDBP00419934
- Locus: chr21-41218863-41219208
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Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191
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Cell type: RPE, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 49%,
"5_TxWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, PGR, FOXA1, ZNF444, SMARCE1, TEAD1, ELF1, KLF6, ZNF217, ESR1, HNF1B, CTCF, TCF12, JUN, BAF155, GATA6, DPF2, TEAD4, ZNF175, PDX1, TFAP2C, CTBP1, ZBTB48, ZSCAN5A, ERG, ONECUT1, MYC, RAD21, NKX2-1, GABPA, STAT3, NKX3-1, RCOR1, NR3C1, ESRRA, CEBPB, CREB1, GRHL2, TRPS1, ZHX2, IRF1, HDAC2, GATA2, GATAD2B, HCFC1, SMARCA5, NCOA2, RUNX1, SMC1A, CBX1, SIN3A, ZFX, SMAD3, CREBBP, ZXDC, GATA4, PBX4, ARNT, FOXM1, FOS, MED1, ZEB1, CEBPD, PIAS1, TFAP2A, REST, POU2F3, ASH2L, CTBP2, PAX7, WT1, HOXB13, RELA, NEUROD1, HIF1A, GATA3, MAX, NRIP1, MTA1, KLF4, NR2F2, TP53, PKNOX1, NFKB1, ELF3, AR, HSF1, JUND, BRD4, CUX1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): RSPH1,MX1,RIPK4,UMODL1,C2CD2,TMPRSS2,SLC37A1,PDE9A,BACE2,PRDM15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000157601,
ENSG00000184012,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:40900000-40925000~~chr21:41200000-41225000,
chr21:40925000-40950000~~chr21:41200000-41225000,
chr21:41200000-41225000~~chr21:41450000-41475000,
chr21:41200000-41225000~~chr21:41700000-41725000,
chr21:41200000-41225000~~chr21:41750000-41775000,
chr21:41200000-41225000~~chr21:41825000-41850000,
chr21:41200000-41225000~~chr21:41950000-41975000,
chr21:41200000-41225000~~chr21:42100000-42125000,
chr21:41200000-41225000~~chr21:42475000-42500000,
chr21:41200000-41225000~~chr21:42650000-42675000,