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Basic information

CohesinDB ID: CDBP00419937

Locus: chr21-41223341-41223563

Data sourse: GSE206145-NatGen2015, GSE25021

Cell type: MCF-7, Fibroblast

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 52%, "5_TxWk": 37%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, PGR, BCL6, PPARG, CHD8, MYCN, TBL1X, MTA3, FOSL1, ZFX, CTBP1, XBP1, CREM, ZBTB48, WT1, STAT1, FOXA1, TET2, YY1, RELA, ZNF384, JUNB, ATF3, MYC, EHMT2, ARID1B, RAD21, SP140, GRHL3, ARNT, SOX11, RXRA, ATF4, ATF2, POU5F1, MGA, TAL1, MAX, APC, STAT3, ZNF143, FOS, CDK8, NFE2, NCOA3, ZNF121, CREB1, NFE2L2, MLLT1, ESR1, OCA2, C11orf30, L3MBTL2, HDAC8, NFKB1, USF2, CTCF, JUN, ZHX2, BCL11A, NR4A1, AR, DPF2, ATF7, E2F4, HSF1, RNF2, NR2C2, BRD4, JUND, ZNF263, CLOCK, E2F1, MAZ, AATF, ATF1, STAG1

Target gene symbol (double-evidenced CRMs): TMPRSS2,RSPH1,UMODL1,SLC37A1,PDE9A,BACE2,PRDM15,C2CD2,MX1,RIPK4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000182240, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160188, ENSG00000160190, ENSG00000160191,

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Deatailed information for cohesin site CDBP00419937