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Basic information

CohesinDB ID: CDBP00419959

Locus: chr21-41303650-41304823

Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 43%, "15_Quies": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, NCOA2, TRP47, TRIM25, CHD8, POU2F2, FOXA2, MYCN, POU5F1, AGO1, KDM4C, NME2, ZFX, XBP1, NFKBIA, SMAD3, ZBTB48, KDM4B, ZSCAN5A, CDK9, ERG, YY1, RELA, CREBBP, HNRNPK, ASCL1, OGG1, ATF3, MYC, CDK6, THAP1, CTCFL, SP140, NRF1, GRHL3, HIF1A, CBFB, GABPA, MAF1, STAT3, NCAPH2, TAL1, ZNF143, CHD1, AGO2, PRDM14, MED1, PLAG1, NCOA3, TERF1, TRIM28, CREB1, NR2F1, EZH2, ESR1, OCA2, L3MBTL2, CTCF, ZHX2, SPI1, GSPT2, AR, CBFA2T2, PCBP1, RXR, REST, ZNF479, HEXIM1, TFIIIC, HSF1, FLI1, NOTCH3, BRD4, CLOCK, MAZ, AATF, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): FAM3B,RIPK4,TMPRSS2,MX1,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956,

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Deatailed information for cohesin site CDBP00419959