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Basic information

CohesinDB ID: CDBP00419972

Locus: chr21-41347074-41348539

Data sourse: GSE25021, GSE126755, GSE67783, GSE72082

Cell type: MCF-7, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SMC3,Rad21,SA1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: non-Hub

Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 45%, "14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, XBP1, FOXA1, SUZ12, ZFHX2, TFAP4, MITF, HDAC3, KLF6, LMO2, ESR1, USF2, JUN, CTCF, BAF155, KLF1, LMO1, E2F1, GLIS1, NANOG, POU2F2, MYCN, POU5F1, TOP2A, ZNF263, CTBP1, ZBTB48, ERG2, ARID3A, HNF4G, ERG, HOXC5, MYC, RFX1, RAD21, GRHL3, PROX1, GABPA, APC, STAT3, NKX3-1, PRDM14, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, GRHL2, ZHX2, SPI1, HDAC2, GATA2, SIX2, FLI1, HCFC1R1, RUNX1, SMC1A, BCL6, CEBPA, EZH2phosphoT487, ZFX, SMAD3, TET2, ERG3, CBX8, PRDM10, CREBBP, ZNF384, RUNX2, GATA4, PBX4, DAXX, ARNT, FOS, CSNK2A1, MYB, PIAS1, KLF9, RBM22, USF1, BCL11A, ARID1A, ASH2L, FOXP1, SMC3, STAG1, TRP47, FOXA2, TBL1X, WT1, HOXB13, YY1, RELA, BRG1, SP140, HIF1A, GATA3, TAL1, NRIP1, GATA1, AGO2, ZNF143, CBX2, TLE3, TP53, ZNF334, EGR2, ARRB1, PAX3-FOXO1, AR, EGLN2, NOTCH3, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 60

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000183844,

eachgene

Deatailed information for cohesin site CDBP00419972