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Basic information

CohesinDB ID: CDBP00419979

Locus: chr21-41357146-41357972

Data sourse: GSE206145-GSE177045, GSE86191

Cell type: MCF-7, HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 58%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, SOX2, XBP1, FOXA1, HLF, RXRB, MLL4, KDM3A, TFAP4, SIN3B, HDGF, TSC22D4, LYL1, ATF3, NFIC, BMI1, ZFP64, ZNF362, ZBTB5, CHD7, CTCFL, RUNX3, CBFB, MXD4, PAX5, MITF, BACH2, MAF, JMJD1C, KLF5, ELF1, TRIM28, TEAD1, RBM39, BCLAF1, KLF6, INTS11, ZNF217, ESR1, OCA2, LMO2, SMAD5, ETV1, USF2, CTCF, TCF12, JUN, BAF155, ARID5B, EP300, LMO1, SND1, SOX5, SOX9, DPF2, DMAP1, IRF4, TRIM24, PRKDC, E2F1, SMC1, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, GTF2F1, TFAP2C, RBPJ, EED, NANOG, POU2F2, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, BRD3, CDK7, RUNX1T1, MTA2, TOP2A, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, NBN, ARID3A, TBP, HNF4G, ERG, PBX1, ASCL1, OGG1, ZNF341, ZNF597, MYC, MCM5, EOMES, SMARCA4, ETS1, RAD21, GRHL3, PROX1, NKX2-1, BATF3, GABPA, MCRS1, APC, XRCC5, ZNF614, NKX3-1, STAT3, IKZF1, RCOR1, HNRNPH1, DNMT3B, NR2F6, CD74, VDR, NR3C1, CEBPB, NFE2, TERF2, HNRNPL, STAT5B, KMT2A, CREB1, EZH2, TBL1XR1, BMPR1A, GRHL2, GABPB1, ZHX2, SPI1, MIXL1, TFE3, HBP1, IRF1, HDAC2, GATA2, ZNF644, GATAD2B, MXD3, ZSCAN29, FLI1, HCFC1, ZGPAT, MXI1, SMARCA5, DRAP1, RELB, HCFC1R1, NFIL3, ZNF316, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, SIRT6, NKX2-2, SIN3A, ZFX, SOX13, AFF4, POU4F2, SMAD3, TET2, ERG3, ZNF770, SP5, TRIM22, ZNF18, MEF2A, CREBBP, ZBTB2, RARA, NOTCH1, ZNF384, RUNX2, SMAD2, GATA4, ARNT, BACH1, SOX11, PBX4, TFDP1, ZNF48, PRDM9, SMAD4, ATF2, ETV6, FOXM1, PBX3, CHD1, CDK8, HMGXB4, TGIF2, FOS, MED1, SUPT5H, TEAD3, ZEB1, KDM6B, MYB, PML, PIAS1, SMAD1, TERF1, ZMYM3, MBD1, STAT5A, ZNF22, RBM22, USF1, SP1, TFAP2A, NIPBL, HNF4A, BCL11A, IKZF5, REST, ATF7, ASH2L, HNRNPLL, TCF3, BCOR, AATF, SMC3, STAT2, STAG1, MLLT1, NFATC3, SKI, TRP47, ZNF283, MEF2B, PPARG, AGO1, FOXA2, EBF1, CREM, ZNF207, E2F8, MIER2, MTA3, CHD2, WT1, ZBED1, GTF2B, HDAC6, MEIS1, MEF2C, TCF7, CDK9, ZNF580, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, MCM3, SP140, TCF4, HIF1A, SKIL, ZFP36, BHLHE22, GATA3, BATF, TAL1, MAX, NRIP1, SPIB, ZNF143, AGO2, GATA1, PLAG1, KLF4, CEBPG, BCL11B, ZNF141, NCOA3, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ZNF687, MED, ZNF334, NFKB1, T, ELF3, KAT8, BRD2, TBX21, BHLHE40, AR, ARID4B, NFKBIZ, ZBTB16, TAF1, YAP1, ZBTB40, EGLN2, ZBTB42, EGR1, RB1, MYNN, HSF1, IKZF2, ZBTB26, BRD4, JUND, RNF2, CUX1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TMPRSS2,MX2,BACE2,RIPK4,PRDM15,MX1,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 64

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956,

eachgene

Deatailed information for cohesin site CDBP00419979