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Basic information

CohesinDB ID: CDBP00419984

Locus: chr21-41368785-41370859

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE25021, GSE165895, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, GSE106870, GSE145327, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, GSE111913, ENCSR054FKH, GSE68388, GSE50893, GSE126755, GSE64758

Cell type: MDM, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, GM12890, GM2255, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Ramos, HCT-116, HEK293T, Hep-G2, HUVEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 26% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.456

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 20%, "2_TssAFlnk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, PAX5, TEAD1, OCA2, SOX5, E2F4, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, CD74, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, SOX11, ATF2, FOXM1, PIAS1, SMAD1, NR1H2, C11orf30, IKZF5, ELL2, ETV4, NFATC3, MEF2B, ZNF207, CREM, CHD2, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, MCM3, TCF4, ZFP36, BATF, SPIB, KLF4, BCL11B, MED, EGR2, ELF3, ARID4B, RXR, ZBTB26, NCOR1, HSF1, SCRT1, ZNF316, FOSL1, XBP1, PBX2, TSC22D4, THRB, ATF3, ZFP64, RUNX3, CBFB, DPF1, MITF, JMJD1C, MAF, ELF1, SNAI2, KLF10, SMAD5, JUN, CTCF, MNT, DPF2, RYBP, IRF4, PDX1, RBPJ, MLX, TFAP2C, YBX1, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, NBN, CHD4, KDM4A, HOMEZ, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, GRHL2, ZNF146, SMARCA5, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, AFF4, DAXX, ARNT, BACH1, ZNF48, PBX3, ETV6, HMGXB4, TEAD3, DIDO1, U2AF1, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, SMC3, MLLT1, STAG1, STAG2, TRP47, AGO1, MTA3, EBF1, ZNF580, BCL3, KDM1A, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, IKZF2, BRD4, JUND, CUX1, PGR, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SND1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, KDM4C, ERG2, TBP, HNF4G, HOXC5, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, NFE2L1, SPI1, ZNF786, PCBP1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, CREBBP, ZNF384, NFYC, TAF15, SMAD4, CDK8, ZEB1, SPDEF, NCOA1, RBM22, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, GTF2B, ZNF662, TCF7, FOXO3, RELA, TARDBP, SKIL, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, PKNOX1, AR, PAX3-FOXO1, HEXIM1, AHR, DMAP1, FOSL2, HMG20A, RBFOX2, ZFHX2, NFIC, CTCFL, CDX2, ZNF629, ZNF506, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, CREB3, RAD51, E2F1, TEAD4, FOXA3, ZNF175, EED, BRD1, MYCN, RUNX1T1, GATAD1, ARID3A, ZNF341, MCM5, RAD21, GRHL3, ZNF614, XRCC5, NFE2, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, PTBP1, SMC1A, MAFG, FIP1L1, ZFX, SMAD3, PRPF4, NOTCH1, RUNX2, GATA4, PBX4, NRF1, NR2C1, FOS, SUPT5H, MED1, CEBPD, MYB, VEZF1, L3MBTL2, NIPBL, ZBTB7A, POU2F3, TCF3, SKI, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, YY1, BRCA1, SP140, BHLHE22, GATA1, CEBPG, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RIPK4,PRDM15,BACE2,MX1,TMPRSS2,MX2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 11

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956,

eachgene

Deatailed information for cohesin site CDBP00419984