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Basic information

CohesinDB ID: CDBP00419985

Locus: chr21-41373113-41380866

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, GSE25021, GSE115602, ENCSR000BTU, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, GSE112028, ENCSR703TNG, GSE145327, GSE118494, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: MDM, GM2610, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, BCBL-1, GM18486, DKO, H1-hESC, Monocytes, MB157, GM12878, SK-N-SH, RT-112, HeLa-Tet-On, GM19099, HUES64, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, GM19238, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 19% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.656

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 25%, "4_Tx": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, NME2, SUZ12, RBFOX2, ZFHX2, HDGF, ATF3, CTCFL, KLF14, TEAD1, SNAI2, ESR1, CTCF, JUN, KLF1, LMO1, SOX5, ZNF776, TFAP2C, BRD1, MYCN, ZNF263, TOP2A, ZBTB48, ZSCAN5A, DDX5, ERG2, OGG1, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, XRCC5, PRDM14, IKZF1, DNMT3B, NR3C1, ESRRA, EZH2, SPI1, RUNX1, SMC1A, SOX13, ZFX, TET2, ERG3, CREBBP, ZNF384, NOTCH1, RUNX2, GATA4, NRF1, ZNF48, PRDM9, FOS, ZEB1, MYB, ZMYM3, RBM22, BCL11A, FOXP1, AATF, ZNF623, SMC3, STAG1, TRP47, CBFA2T2, FOXA2, AGO1, EBF1, WT1, HOXB13, KDM1A, RELA, SP140, TCF4, TAL1, ZNF143, AGO2, CBX2, ZKSCAN8, NR2F1, ZNF334, ZSCAN22, EGR2, AR, HSF1, NCOR1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): FAM3B,PRDM15,MX2,MX1,RIPK4,TMPRSS2,BACE2

Function elements

Human SNPs: Nevus_count_or_cutaneous_melanoma

Number of somatic mutations (coding): 176

Number of somatic mutations (non-coding): 144

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956,

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Deatailed information for cohesin site CDBP00419985