- Basic information
- CohesinDB ID: CDBP00419992
- Locus: chr21-41392802-41395480
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE67783, GSE86191, GSE98367, GSE105028, GSE206145-NatGen2015, GSE120943, GSE103477, ENCSR703TNG
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Cell type: MCF-7, H1-hESC, MDM, Fibroblast, HCT-116, Monocytes, HSPC, Macrophage, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 31%,
"5_TxWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, POU2F2, PGR, MYCN, ZNF263, SIN3A, ZFX, XBP1, WT1, ZBTB48, FOXA1, ERG3, DDX5, SUZ12, YY1, RELA, CREBBP, ZNF384, ATF3, MYC, MCM5, GATA4, MCM3, SP140, RAD21, GRHL3, GATA3, GABPA, MAX, PAX5, NRIP1, ZNF143, ZNF467, ESRRA, NCOA3, TRIM28, ESR1, OCA2, GRHL2, ZNF334, CTCF, RBM22, PAX3-FOXO1, ZNF257, AR, PAX8, E2F6, ZNF366, NOTCH3, BRD4, ZNF512B, FOXP1, NCOA2, STAG1, EED
- Target gene symbol (double-evidenced CRMs): BACE2,MX2,TMPRSS2,FAM3B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 11
- Number of somatic mutations (non-coding): 11
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183486,
ENSG00000184012,
- Related loop:
chr21:40175000-40200000~~chr21:41400000-41425000,
chr21:40925000-40950000~~chr21:41375000-41400000,
chr21:41275000-41300000~~chr21:41375000-41400000,
chr21:41375000-41400000~~chr21:41525000-41550000,
chr21:41375000-41400000~~chr21:43200000-43225000,
chr21:41400000-41425000~~chr21:41500000-41525000,
chr21:41400000-41425000~~chr21:41600000-41625000,