- Basic information
- CohesinDB ID: CDBP00419994
- Locus: chr21-41399454-41400168
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Data sourse: GSE103477, GSE67783, GSE86191
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Cell type: MDM, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"4_Tx": 31%,
"15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, FOXA1, SUZ12, LYL1, CBFB, MECOM, PAX5, TP63, JMJD1C, TEAD1, TRIM28, ELF1, KLF6, ETV1, ZNF217, ESR1, MLL, LMO2, USF2, JUN, TCF12, CTCF, EP300, MNT, GATA6, DPF2, TRIM24, RFX5, PRKDC, E2F1, KMT2B, GTF2F1, TFAP2C, POU2F2, CHD8, ZSCAN5D, POU5F1, ZNF263, RUNX1T1, MYCN, CTBP1, ZBTB48, ZSCAN5A, STAT1, MLLT3, DDX5, HNF4G, ERG, ASCL1, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, NKX3-1, IKZF1, NFE2, RCOR1, VDR, NR3C1, ESRRA, CEBPB, KMT2A, CREB1, EZH2, GRHL2, TRPS1, SPI1, IRF1, HDAC2, GATA2, FLI1, ZNF490, RUNX1, SMC1A, CBX1, CEBPA, SIN3A, ZFX, SMAD3, ZNF770, CBX8, SMARCC1, CREBBP, CDK6, GR, ARNT, DAXX, PBX4, ATF2, ZNF48, ETV6, FOS, CDK8, MED1, ZEB1, SPDEF, MYB, SCRT2, PIAS1, STAT5A, RBM22, BCL11A, SP1, TFAP2A, NR4A1, HNF4A, ZNF479, ATF7, ASH2L, TCF3, FOXP1, SMC3, ELL2, STAG1, SKI, FOXA2, EBF1, WT1, MEF2C, CDK9, ZKSCAN1, KDM1A, YY1, RELA, SP140, ZFP36, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, AGO2, PLAG1, KLF4, CEBPG, NR2F2, TCF7L2, KDM5B, TP53, ZNF687, PKNOX1, ELF3, AR, ZBTB16, RXR, EGLN2, RB1, HSF1, RNF2, BRD4, SCRT1, JUND, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): BACE2,TMPRSS2,FAM3B,MX2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 1
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183486,
ENSG00000184012,
- Related loop:
chr21:40175000-40200000~~chr21:41400000-41425000,
chr21:40925000-40950000~~chr21:41375000-41400000,
chr21:41275000-41300000~~chr21:41375000-41400000,
chr21:41375000-41400000~~chr21:41525000-41550000,
chr21:41375000-41400000~~chr21:43200000-43225000,
chr21:41400000-41425000~~chr21:41500000-41525000,
chr21:41400000-41425000~~chr21:41600000-41625000,