- Basic information
- CohesinDB ID: CDBP00420001
- Locus: chr21-41418958-41421549
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Data sourse: GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE115602, GSE165895, GSE93080, GSE67783, GSE86191, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, GSE106870, ENCSR338DUC, GSE98367, GSE206145, GSE85526, ENCSR000ECE, GSE62063, ENCSR000BMY, GSE55407, ENCSR000BTQ, GSE129526, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS
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Cell type: MDM, GM2610, CVB-hiPSC, OCI-AML-3, Liver, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, HEKn, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, MB157, Lymphoblast, GM12878, GM2588, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, Ramos, MCF-7, HCT-116, HEK293T, Hep-G2, HCAEC, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 25% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.556
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"1_TssA": 21%,
"2_TssAFlnk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, ZBTB44, IKZF3, PAX5, SFPQ, TEAD1, LMO2, OCA2, ZNF561, SOX5, ZNF528, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, ZNF263, CTBP1, STAT1, ZNF134, SAP130, ERG, EZH1, SMARCA4, RFX1, TOP1, ZNF398, CD74, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, RELB, RUNX1, CEBPA, NKX2-2, IRF3, HDAC1, SP5, TRIM22, SMARCC1, PRDM10, ATF2, FOXM1, SP2, SMARCB1, PIAS1, STAT5A, GSPT2, IKZF5, MBD2, ELL2, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, MPHOSPH8, TCF4, ZFP36, SPIB, ZFP69B, BCL11B, KLF4, ZNF281, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, ILF3, ZNF660, XBP1, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, MITF, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, ZBTB20, RYBP, DPF2, IRF4, RBPJ, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, NBN, CHD4, PBX1, KDM4A, HOMEZ, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, ZSCAN29, SMARCA5, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, AFF4, SP3, ARNT, DAXX, ZNF48, ZEB2, ETV6, MAFB, ZNF10, NCAPH2, HMGXB4, TEAD3, ZXDB, TAF7, KLF9, SP1, BCL11A, ZNF479, ATF7, ASH2L, GLIS2, PRDM6, SMC3, STAT2, STAG1, MLLT1, ZNF394, AGO1, MTA3, EBF1, MAFF, ZNF580, KDM1A, ZNF266, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, TP53, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, ZSCAN23, IRF9, PGR, SOX2, PATZ1, UBTF, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, KLF6, ZNF217, ESR1, SAP30, KLF1, E2F6, TRIM24, PRKDC, GTF2F1, GLIS1, POU2F2, KDM4C, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, ETS1, MYC, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF384, RARA, ZNF35, TAF15, NFYC, SMAD4, CDK8, CSNK2A1, ZEB1, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, ZNF318, RELA, TARDBP, SKIL, MAX, TCF7L2, NR2F1, KDM5B, PKNOX1, AR, KMT2D, YAP1, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, E2F7, SUZ12, RBFOX2, ZFHX2, CTCFL, PRDM1, KLF14, ZNF629, TRIM28, BCLAF1, ETV1, RCOR2, MLL, TCF12, EP300, BAF155, GATA6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, MLLT3, GATAD1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, HBP1, EHF, TFE3, IRF1, ZGPAT, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, IRF2, NOTCH1, RUNX2, GATA4, NRF1, PBX4, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, SCRT2, L3MBTL2, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, NOTCH3, MAZ, BRCA1
- Target gene symbol (double-evidenced CRMs): TMPRSS2,MX1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 4
- Number of somatic mutations (non-coding): 8
- Related genes and loops
- Related gene:
ENSG00000157601,
ENSG00000184012,
- Related loop:
chr21:39600000-39625000~~chr21:41425000-41450000,
chr21:39700000-39725000~~chr21:41425000-41450000,
chr21:39900000-39925000~~chr21:41425000-41450000,
chr21:40175000-40200000~~chr21:41400000-41425000,
chr21:40775000-40800000~~chr21:41425000-41450000,
chr21:40800000-40825000~~chr21:41425000-41450000,
chr21:41000000-41025000~~chr21:41425000-41450000,
chr21:41125000-41150000~~chr21:41425000-41450000,
chr21:41150000-41175000~~chr21:41425000-41450000,
chr21:41175000-41200000~~chr21:41425000-41450000,
chr21:41275000-41300000~~chr21:41425000-41450000,
chr21:41300000-41325000~~chr21:41425000-41450000,
chr21:41361000-41363181~~chr21:41425246-41427778,
chr21:41400000-41425000~~chr21:41500000-41525000,
chr21:41400000-41425000~~chr21:41600000-41625000,
chr21:41425000-41450000~~chr21:41525000-41550000,
chr21:41425000-41450000~~chr21:41550000-41575000,
chr21:41425000-41450000~~chr21:41575000-41600000,
chr21:41425000-41450000~~chr21:41600000-41625000,
chr21:41425000-41450000~~chr21:41725000-41750000,
chr21:41425000-41450000~~chr21:41750000-41775000,
chr21:41425000-41450000~~chr21:41925000-41950000,
chr21:41425000-41450000~~chr21:42125000-42150000,
chr21:41425000-41450000~~chr21:42200000-42225000,
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41425000-41450000~~chr21:42825000-42850000,
chr21:41425000-41450000~~chr21:45125000-45150000,