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Basic information

CohesinDB ID: CDBP00420004

Locus: chr21-41423769-41424317

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE98367, GSE120943, GSE103477

Cell type: MCF-7, MDM, HCT-116, Monocytes, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 49%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NCOA2, PGR, BCL6, POU2F2, LDB1, EZH2phosphoT487, ZFX, NME2, ZBTB48, STAT1, FOXA1, DDX5, NBN, YY1, RELA, HDGF, CREBBP, TARDBP, ZBTB2, MYC, RAD21, ATF2, TAL1, ZSCAN4, NRIP1, GATA1, IKZF1, NFE2, DNMT3B, KLF4, NCOA3, ELF1, TRIM28, TFAP2C, CREB1, MLLT1, ESR1, PKNOX1, ZFP42, BCL11A, SPI1, KLF1, TFAP2A, AR, GATA2, ATF7, HSF1, HCFC1, BRD4, GLIS2, MAZ, ZNF528, NFYB, STAT2, STAG1, AHR

Target gene symbol (double-evidenced CRMs): MX1,TMPRSS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000157601, ENSG00000184012,

eachgene

Deatailed information for cohesin site CDBP00420004