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Basic information

CohesinDB ID: CDBP00420005

Locus: chr21-41425596-41431302

Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE116868, GSE105028, GSE103477, GSE111537, GSE25021, GSE131606, GSE165895, ENCSR917QNE, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, GSE94872, GSE98367, GSE206145, GSE85526, ENCSR000BMY, GSE111913, GSE155324, GSE68388, GSE50893, GSE126755

Cell type: MDM, GM10847, GM2610, OCI-AML-3, HSPC, Liver, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, HEKn, GM12890, GM2255, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM2588, GM19239, RT-112, Macrophage, MCF-7, GM12892, HCT-116, Hep-G2, HUVEC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.600

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 19%, "2_TssAFlnk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, NME2, XBP1, FOXA1, SUZ12, RBFOX2, RING1B, UBTF, KDM3A, HDGF, ATF3, ZFP64, CTCFL, RUNX3, CHD7, CBFB, MXD4, PAX5, TP63, MITF, BACH2, MAF, KLF5, ELF1, BCLAF1, TRIM28, KLF6, SNAI2, RBM39, TEAD1, SMAD5, ESR1, SAP30, OCA2, USF2, CTCF, TCF12, JUN, EP300, MNT, SOX9, SOX5, RYBP, DPF2, PAX8, DMAP1, E2F6, IRF4, RFX5, E2F1, TEAD4, GTF2F1, GATAD2A, RBPJ, EED, TFAP2C, JARID2, POU2F2, NANOG, BRD1, ZSCAN5D, ZNF263, MYCN, BRD3, POU5F1, MTA2, ZBTB48, ZSCAN5A, STAT1, NONO, SAP130, NBN, ARID3A, DDX5, TBP, HOXC5, ERG, PBX1, OGG1, ZNF341, ETS1, MYC, EZH1, SMARCA4, KDM4A, RAD21, GRHL3, RXRA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, NFE2, VDR, NR3C1, STAT5B, HNRNPL, KMT2A, CREB1, EZH2, GABPB1, PHF8, ZHX2, SPI1, IRF1, PCBP1, HDAC2, GATAD2B, MXD3, FLI1, HCFC1, ZGPAT, DRAP1, SMARCA5, RELB, ZNF316, ETV5, RUNX1, THAP11, BCL6, SMC1A, MAFG, EZH2phosphoT487, NKX2-2, SIRT6, SOX13, AFF4, ZFX, SIN3A, TET2, CBX8, ERG3, SP5, ZNF770, TRIM22, ZNF18, SMARCC1, MEF2A, CREBBP, NFYC, NOTCH1, RUNX2, ARNT, BACH1, TFDP1, NRF1, ZNF48, SMAD4, PBX3, NCAPH2, MAFB, CHD1, SUPT5H, HMGXB4, MED1, ZEB1, PML, TEAD3, MYB, KDM6B, ZMYM3, SMAD1, C11orf30, MAFK, SP1, NIPBL, BCL11A, HNF4A, IKZF5, REST, ARID2, ASH2L, HNRNPLL, PCGF2, TCF3, BCOR, FOXP1, AATF, SMC3, STAT2, NCOR2, MLLT1, STAG1, NFATC3, AGO1, TRP47, CBFA2T2, MEF2B, PPARG, TBL1X, ZNF207, RBBP5, CREM, CHD2, FOXA2, HDAC6, EBF1, GTF2B, MAFF, MTA3, WT1, ZBTB33, CDK9, ZNF580, BCL3, KDM1A, YY1, RELA, TARDBP, BRCA1, SP140, TCF4, HIF1A, PCGF1, BHLHE22, GATA3, BATF, MAX, ZNF143, AGO2, KLF4, BCL11B, NR2F1, KDM5B, ZNF687, TP53, IRF5, PKNOX1, NFKB1, BRD2, RBM14, KAT8, TBX21, BHLHE40, AR, NFKBIZ, TAF1, ARID4B, ZBTB40, RXR, EGLN2, EGR1, RB1, TFIIIC, HSF1, ZBTB26, IKZF2, BRD4, RNF2, HEXIM1, JUND, SCRT1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): C2CD2,B3GALT5,BACE2,MX1,ABCG1,UMODL1,WDR4,MX2,TMPRSS2,RIPK4,PCP4,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 74

Number of somatic mutations (non-coding): 27

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183036, ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160193,

eachgene

Deatailed information for cohesin site CDBP00420005