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Basic information

CohesinDB ID: CDBP00420006

Locus: chr21-41431562-41433383

Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE86191, GSE105028, ENCSR000BMY, GSE103477, GSE50893

Cell type: MDM, GM18526, HCT-116, SNYDER, GM19240, GM12878, GM2588, GM2255, HSPC, GM18486, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 29%, "5_TxWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, FOXA1, HDGF, NFIC, RUNX3, CHD7, CBFB, PAX5, HDAC3, ELF1, BCLAF1, TEAD1, TRIM28, ZNF217, ESR1, SMAD5, CTCF, TCF12, BAF155, DPF2, PAX8, IRF4, PRKDC, RBPJ, TFAP2C, EED, POU2F2, NANOG, ZSCAN5D, ZNF263, MYCN, POU5F1, MTA2, ZNF317, DUX4, NBN, HNF4G, ERG, PBX1, MYC, SMARCA4, RAD21, GRHL3, NKX3-1, IKZF1, TERF2, VDR, NR3C1, KMT2A, CREB1, FEZF1, SPI1, HDAC2, GATA2, GATAD2B, NCOA2, RUNX1, BCL6, SMC1A, SIN3A, ZFX, MEF2A, CREBBP, GATA4, GR, ARNT, DAXX, BACH1, ATF2, ETV6, PBX3, MED1, CSNK2A1, TERF1, PML, PIAS1, NCOA1, SETDB1, MAFK, SP1, BCL11A, HNF4A, ARID1A, ASH2L, BCOR, TCF3, FOXP1, NCOR2, MLLT1, STAG1, ZNF283, MEF2B, FOXA2, EBF1, CREM, HDAC6, ZBED1, GTF2B, WT1, ZBTB33, CDK9, HOXB13, YY1, RELA, ZNF19, TARDBP, BRG1, ZFP36, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, PLAG1, TLE3, NCOA3, NR2F1, MED, T, BHLHE40, AR, TAF1, RB1, BRD4, MAZ, ZNF440

Target gene symbol (double-evidenced CRMs): MX1,ABCG1,TMPRSS2,WDR4,PCP4,FAM3B,B3GALT5,UMODL1,RIPK4,C2CD2,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 134

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183036, ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160193,

eachgene

Deatailed information for cohesin site CDBP00420006