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Basic information

CohesinDB ID: CDBP00420008

Locus: chr21-41438421-41440223

Data sourse: GSE103477, GSE206145-NatGen2015, GSE120943, GSE86191

Cell type: MDM, Fibroblast, HCT-116, Monocytes

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 41%, "15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, POU2F2, CTNNB1, CEBPA, FOXA2, CHD2, ZFX, POU4F2, XBP1, WT1, ZSCAN5A, FOXA1, DDX5, PBX2, SMARCC1, ERG, RELA, MYC, NFIC, GATA4, RAD21, CHD7, GRHL3, GATA3, PBX3, GATA1, CDK8, ZNF143, VDR, PLAG1, CEBPB, JMJD1C, ESRRA, MYB, ESR1, PKNOX1, KLF9, PITX3, ZNF334, STAT5A, CTCF, TCF12, SPI1, KLF1, AR, PAX3-FOXO1, GATA2, BRD4, FOXP1, MAZ, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): RIPK4,UMODL1,TMPRSS2,BACE2,PCP4,MX1,B3GALT5,C2CD2,WDR4,ABCG1,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 140

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183036, ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160193,

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Deatailed information for cohesin site CDBP00420008