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Basic information

CohesinDB ID: CDBP00420009

Locus: chr21-41440635-41442106

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, GSE120943, GSE103477

Cell type: MDM, Fibroblast, HCT-116, Monocytes, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 44%, "15_Quies": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, GLIS1, TRP47, POU2F2, CHD8, FOXA2, MYCN, POU5F1, ZFX, NME2, WT1, ZBTB48, TET2, ERG3, ERG, RELA, TARDBP, ATF3, THAP1, RAD21, SP140, DAXX, GRHL3, MCM3, STAT3, PAX5, ZSCAN4, GATA1, ZNF143, TERF2, ZNF736, KDM6B, BCLAF1, NR2F1, CTCF, BCL11A, AR, FLI1, HSF1, BRD4, FOXP1, MAZ, HCFC1R1, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): TMPRSS2,PCP4,MX1,B3GALT5,WDR4,C2CD2,RIPK4,BACE2,FAM3B,UMODL1,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 510

Number of somatic mutations (non-coding): 102

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183036, ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160193,

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Deatailed information for cohesin site CDBP00420009