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Basic information

CohesinDB ID: CDBP00420010

Locus: chr21-41442477-41454571

Data sourse: GSE105004, GSE206145-GSE177045, GSE67783, GSE86191, GSE98367, GSE138405, GSE206145-NatGen2015, GSE50893, GSE120943, ENCSR000EDE, GSE103477, GSE126990, GSE108869, ENCSR000ECS, GSE165895

Cell type: MCF-7, GM12892, MDM, Fibroblast, HCT-116, Hela-Kyoto, Monocytes, HeLa-S3, HeLa, GM2255, HSPC, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 39%, "5_TxWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, POU2F2, FOXA2, HDAC6, ZFX, FOXA1, RELA, ZNF384, OGG1, GATA4, RAD21, PBX4, GRHL3, GATA3, TAL1, PBX3, STAT3, FOS, NR3C1, CEBPB, BCLAF1, CREB1, STAT5A, JUN, TCF12, SPI1, EP300, AR, RXR, JUND, TEAD4

Target gene symbol (double-evidenced CRMs): PRDM15,PCP4,RIPK4,MX2,FAM3B,UMODL1,MX1,WDR4,TMPRSS2,C2CD2,BACE2,B3GALT5,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1215

Number of somatic mutations (non-coding): 243

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183036, ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160193,

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Deatailed information for cohesin site CDBP00420010