- Basic information
- CohesinDB ID: CDBP00420011
- Locus: chr21-41454845-41457031
-
Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE103477
-
Cell type: MDM, RPE, HCT-116, RT-112, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
81% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"5_TxWk": 32%,
"4_Tx": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, NFIC, RUNX3, CHD7, CBFB, MORC2, ZSCAN4, TEAD1, BCLAF1, SNAI2, SMAD5, ESR1, OCA2, CTCF, JUN, GATA6, GTF2F1, TFAP2C, EED, POU2F2, NANOG, MYCN, POU5F1, TOP2A, ZBTB48, DUX4, STAT1, ZNF134, DDX5, ASCL1, MYC, RAD21, GRHL3, NKX2-1, STAT3, VDR, NR3C1, CEBPB, EZH2, SPI1, GATA2, MXD3, RUNX1, BCL6, CEBPA, ZFX, TET2, CREBBP, ZNF384, DAXX, ARNT, SOX11, ATF2, SMAD4, ZNF10, FOS, CDK8, ZEB1, PML, TERF1, STAT5A, BCL11A, FOXP1, STAG1, ZNF207, MTA3, FOXA2, NFATC1, GTF2B, WT1, CDK9, BCL3, KDM1A, YY1, RELA, JUNB, SP140, HIF1A, GATA3, MAX, ZNF143, NCOA3, AR, RXR, NCOR1, BRD4, AHR
- Target gene symbol (double-evidenced CRMs): FAM3B,RIPK4,MX1,ABCG1,BACE2,PRDM15,UMODL1,MX2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 20
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183486,
ENSG00000157601,
ENSG00000183421,
ENSG00000141956,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:39600000-39625000~~chr21:41425000-41450000,
chr21:39700000-39725000~~chr21:41425000-41450000,
chr21:39900000-39925000~~chr21:41425000-41450000,
chr21:40125000-40150000~~chr21:41450000-41475000,
chr21:40775000-40800000~~chr21:41425000-41450000,
chr21:40800000-40825000~~chr21:41425000-41450000,
chr21:41000000-41025000~~chr21:41425000-41450000,
chr21:41121201-41122984~~chr21:41459735-41461936,
chr21:41121224-41122886~~chr21:41459709-41461697,
chr21:41121225-41122896~~chr21:41459683-41461603,
chr21:41121237-41123266~~chr21:41459580-41461716,
chr21:41121239-41122909~~chr21:41459867-41462122,
chr21:41121260-41122868~~chr21:41459775-41461692,
chr21:41121357-41122645~~chr21:41460157-41461407,
chr21:41125000-41150000~~chr21:41425000-41450000,
chr21:41125000-41150000~~chr21:41450000-41475000,
chr21:41150000-41175000~~chr21:41425000-41450000,
chr21:41150000-41175000~~chr21:41450000-41475000,
chr21:41175000-41200000~~chr21:41425000-41450000,
chr21:41200000-41225000~~chr21:41450000-41475000,
chr21:41275000-41300000~~chr21:41425000-41450000,
chr21:41275000-41300000~~chr21:41450000-41475000,
chr21:41281909-41284412~~chr21:41459991-41461684,
chr21:41282093-41284330~~chr21:41459685-41461551,
chr21:41282099-41284639~~chr21:41459664-41461786,
chr21:41282110-41284722~~chr21:41459434-41461559,
chr21:41282125-41284316~~chr21:41459620-41461739,
chr21:41282133-41284375~~chr21:41459735-41461936,
chr21:41282147-41284710~~chr21:41459580-41461716,
chr21:41282155-41284690~~chr21:41459307-41461849,
chr21:41282193-41284644~~chr21:41459685-41461836,
chr21:41282205-41284637~~chr21:41459476-41461719,
chr21:41282223-41284326~~chr21:41459674-41461814,
chr21:41282224-41284707~~chr21:41459487-41461757,
chr21:41282240-41284443~~chr21:41459800-41461731,
chr21:41282253-41284285~~chr21:41459934-41461665,
chr21:41282268-41284276~~chr21:41459775-41461692,
chr21:41282269-41284303~~chr21:41459918-41461732,
chr21:41282270-41284305~~chr21:41459683-41461603,
chr21:41282272-41284307~~chr21:41459825-41461718,
chr21:41282272-41284702~~chr21:41459656-41461660,
chr21:41282282-41284347~~chr21:41459502-41461722,
chr21:41282283-41284648~~chr21:41459867-41462122,
chr21:41282284-41284738~~chr21:41459709-41461697,
chr21:41282295-41284287~~chr21:41459726-41462162,
chr21:41282314-41285188~~chr21:41459631-41461654,
chr21:41282316-41284371~~chr21:41459776-41461623,
chr21:41282331-41284316~~chr21:41459997-41461595,
chr21:41282376-41284318~~chr21:41459958-41461683,
chr21:41282419-41284353~~chr21:41459674-41461670,
chr21:41282438-41284308~~chr21:41459812-41461705,
chr21:41282441-41284676~~chr21:41459795-41461716,
chr21:41282471-41284284~~chr21:41459737-41461655,
chr21:41282471-41284317~~chr21:41459729-41461718,
chr21:41282499-41284371~~chr21:41460072-41461492,
chr21:41300000-41325000~~chr21:41425000-41450000,
chr21:41300000-41325000~~chr21:41450000-41475000,
chr21:41350000-41375000~~chr21:41450000-41475000,
chr21:41368487-41370280~~chr21:41458627-41461687,
chr21:41368627-41370590~~chr21:41459655-41461711,
chr21:41368711-41370168~~chr21:41459737-41461655,
chr21:41368727-41370235~~chr21:41460007-41461704,
chr21:41425000-41450000~~chr21:41525000-41550000,
chr21:41425000-41450000~~chr21:41550000-41575000,
chr21:41425000-41450000~~chr21:41575000-41600000,
chr21:41425000-41450000~~chr21:41600000-41625000,
chr21:41425000-41450000~~chr21:41725000-41750000,
chr21:41425000-41450000~~chr21:41750000-41775000,
chr21:41425000-41450000~~chr21:41925000-41950000,
chr21:41425000-41450000~~chr21:42125000-42150000,
chr21:41425000-41450000~~chr21:42200000-42225000,
chr21:41425000-41450000~~chr21:42250000-42275000,
chr21:41425000-41450000~~chr21:42825000-42850000,
chr21:41425000-41450000~~chr21:45125000-45150000,
chr21:41450000-41475000~~chr21:41575000-41600000,
chr21:41450000-41475000~~chr21:41600000-41625000,
chr21:41450000-41475000~~chr21:41700000-41725000,
chr21:41450000-41475000~~chr21:41750000-41775000,
chr21:41450000-41475000~~chr21:41825000-41850000,
chr21:41450000-41475000~~chr21:42100000-42125000,
chr21:41450000-41475000~~chr21:42125000-42150000,
chr21:41450000-41475000~~chr21:42275000-42300000,